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    Ten-year survival after multiple invasive melanomas is worse than after a single melanoma: a population-based study.

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    Authors
    Youlden, D
    Baade, P
    Soyer, H
    Youl, P
    Kimlin, M
    Aitken, J
    Green, Adèle C
    Khosrotehrani, K
    Affiliation
    Cancer Council Queensland, Brisbane, Queensland, AustraliaCancer Council Queensland, Brisbane, Queensland, Australia
    Issue Date
    2016-03-23
    
    Metadata
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    Abstract
    The prognosis of melanoma patients who are diagnosed with multiple primary lesions remains controversial. We used a large, population-based cohort to re-examine this issue, applying a delayed entry methodology to avoid survival bias. Of 32,238 eligible patients diagnosed between 1995 and 2008, 29,908 (93%) had a single invasive melanoma, 2,075 (6%) had two and 255 (1%) had three. Allowing for differences in entry time, 10-year cause-specific survival for these three groups was 89% (95% CI = 88%-90%), 83% (95% CI = 80%-86%) and 67% (95% CI = 54%-81%), respectively. After adjustment for key prognostic factors, the hazard ratio (HR) of death within 10 years from melanoma was two times higher for those with two melanomas (HR = 2.01, 95% CI = 1.57-2.59; p<0.001) and nearly three times higher when three melanomas were diagnosed (HR = 2.91, 95% CI = 1.64-5.18; p<0.001) compared to people with a single melanoma. Melanoma-specific mortality remained elevated after adjusting for maximum thickness or ulceration of any melanoma regardless of the index tumor. After appropriately accounting for the interval between diagnosis of the first and subsequent melanomas, patients with multiple invasive melanomas have significantly poorer survival than patients with a single invasive melanoma.
    Citation
    Ten-year survival after multiple invasive melanomas is worse than after a single melanoma: a population-based study. 2016: J Invest Dermatol
    Journal
    The Journal of Investigative Dermatology
    URI
    http://hdl.handle.net/10541/606631
    DOI
    10.1016/j.jid.2016.03.014
    PubMed ID
    27019458
    Type
    Article
    Language
    en
    ISSN
    1523-1747
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jid.2016.03.014
    Scopus Count
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    All Paterson Institute for Cancer Research

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