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    Immunohistochemical detection of BRAF V600E mutation status in anaplastic thyroid carcinoma.

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    Authors
    Rushton, Sarah
    Burghel, G
    Wallace, A
    Nonaka, Daisuke
    Affiliation
    Department of Histopathology, Christie NHS Foundation Trust, Manchester, UK
    Issue Date
    2016-03-14
    
    Metadata
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    Abstract
    Anaplastic thyroid carcinoma (ATC) is one of the most aggressive adult solid cancers. Due to its rarity, there are only a handful of molecular genetics studies on ATCs (1-3) . BRAF V600E mutation is one of the commonly reported genetic alterations, reported in10-68% of ATCs(1-4) . Currently there is no effective treatment for ATC.,Therapy targeting BRAF may provide a potential therapeutic option as a dramatic response to BRAF inhibitor (vemurafenib) has been reported in a case of BRAF-mutated ATC (5) . A number of studies have shown that BRAF V600E mutant-specific antibody VE1 can identify BRAF V600E mutation in a spectrum of cancers, including thyroid cancers (6) . We investigated the utility of this antibody for BRAF V600E screening in ATCs. This article is protected by copyright. All rights reserved.
    Citation
    Immunohistochemical Detection of BRAF V600E Mutation Status in Anaplastic Thyroid Carcinoma. 2016: Histopathology
    Journal
    Histopathology
    URI
    http://hdl.handle.net/10541/605663
    DOI
    10.1111/his.12964
    PubMed ID
    26987976
    Type
    Article
    Language
    en
    ISSN
    1365-2559
    ae974a485f413a2113503eed53cd6c53
    10.1111/his.12964
    Scopus Count
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