Lack of correlation between stem-cell proliferation and radiation- or smoking-associated cancer risk.
AffiliationRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Rockville, Maryland
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AbstractA recent paper by Tomasetti and Vogelstein (Science 2015 347 78-81) suggested that the variation in natural cancer risk was largely explained by the total number of stem-cell divisions, and that most cancers arose by chance. They proposed an extra-risk score as way of distinguishing the effects of the stochastic, replicative component of cancer risk from other causative factors, specifically those due to the external environment and inherited mutations.
CitationLack of Correlation between Stem-Cell Proliferation and Radiation- or Smoking-Associated Cancer Risk. 2016, 11 (3):e0150335 PLoS ONE
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