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    Clinical outcomes and survival following treatment of metastatic castrate-refractory prostate cancer with docetaxel alone or with strontium-89, zoledronic acid, or both: the TRAPEZE randomized clinical trial.

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    Authors
    James, N
    Pirrie, S
    Pope, A
    Barton, D
    Andronis, L
    Goranitis, I
    Collins, S
    Daunton, A
    McLaren, D
    O'Sullivan, J
    Parker, C
    Porfiri, E
    Staffurth, J
    Stanley, A
    Wylie, James P
    Beesley, S
    Birtle, A
    Brown, J
    Chakraborti, P
    Hussain, S
    Russell, M
    Billingham, L
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    Affiliation
    University Hospital Birmingham NHS Foundation Trust, Birmingham, England
    Issue Date
    2016-01-21
    
    Metadata
    Show full item record
    Abstract
    Bony metastatic castrate-refractory prostate cancer (CRPC) has a poor prognosis and high morbidity. Zoledronic acid (ZA) is commonly combined with docetaxel in practice but lacks evidence that combining is effective, and strontium-89 (Sr89) is generally used palliatively in patients unfit for chemotherapy. Phase 2 analysis of the TRAPEZE trial confirmed combining the agents was safe and feasible, and the objectives of phase 3 include assessment of the treatments on survival.
    Citation
    Clinical outcomes and survival following treatment of metastatic castrate-refractory prostate cancer with docetaxel alone or with strontium-89, zoledronic acid, or both: the TRAPEZE randomized clinical trial.. 2016: JAMA Oncol
    Journal
    JAMA Oncology
    URI
    http://hdl.handle.net/10541/600561
    DOI
    10.1001/jamaoncol.2015.5570
    PubMed ID
    26794729
    Type
    Article
    Language
    en
    ISSN
    2374-2445
    ae974a485f413a2113503eed53cd6c53
    10.1001/jamaoncol.2015.5570
    Scopus Count
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