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    Protocol for PIT: a phase III trial of prophylactic irradiation of tracts in patients with malignant pleural mesothelioma following invasive chest wall intervention.

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    Authors
    Bayman, Neil A
    Ardron, D
    Ashcroft, Linda
    Baldwin, D
    Booton, R
    Darlison, L
    Edwards, J
    Lang-Lazdunski, L
    Lester, J
    Peake, M
    Rintoul, R
    Snee, M
    Taylor, Paul
    Lunt, C
    Faivre-Finn, Corinne
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    Affiliation
    Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK
    Issue Date
    2016
    
    Metadata
    Show full item record
    Abstract
    Histological diagnosis of malignant mesothelioma requires an invasive procedure such as CT-guided needle biopsy, thoracoscopy, video-assisted thorascopic surgery (VATs) or thoracotomy. These invasive procedures encourage tumour cell seeding at the intervention site and patients can develop tumour nodules within the chest wall. In an effort to prevent nodules developing, it has been widespread practice across Europe to irradiate intervention sites postprocedure-a practice known as prophylactic irradiation of tracts (PIT). To date there has not been a suitably powered randomised trial to determine whether PIT is effective at reducing the risk of chest wall nodule development.
    Citation
    Protocol for PIT: a phase III trial of prophylactic irradiation of tracts in patients with malignant pleural mesothelioma following invasive chest wall intervention. 2016, 6 (1):e010589 BMJ Open
    Journal
    BMJ Open
    URI
    http://hdl.handle.net/10541/596613
    DOI
    10.1136/bmjopen-2015-010589
    PubMed ID
    26817643
    Type
    Article
    Language
    en
    ISSN
    2044-6055
    ae974a485f413a2113503eed53cd6c53
    10.1136/bmjopen-2015-010589
    Scopus Count
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    All Christie Publications

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