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    (18)F-FLT PET imaging of cellular proliferation in pancreatic cancer.

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    Authors
    Lamarca, Angela
    Asselin, Marie-Claude
    Manoharan, Prakash
    McNamara, Mairéad G
    Trigonis, I
    Hubner, Richard A
    Saleem, Azeem
    Valle, Juan W
    Affiliation
    Dept of Medical Oncology, The Christie NHS FT, Manchester
    Issue Date
    2015-12-29
    
    Metadata
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    Abstract
    Pancreatic ductal adenocarcinoma is known for its poor prognosis. Since the development of computerized tomography, magnetic resonance and endoscopic ultrasound, novel imaging techniques have struggled to get established in the management of patients diagnosed with pancreatic adenocarcinoma for several reasons. Thus, imaging assessment of pancreatic cancer remains a field with scope for further improvement. In contrast to cross-sectional anatomical imaging methods, molecular imaging modalities such as positron emission tomography (PET) can provide information on tumour function. Particularly, tumour proliferation may be assessed by measurement of intracellular thymidine kinase 1 (TK1) activity level using thymidine analogues radiolabelled with a positron emitter for use with PET. This approach, has been widely explored with [(18)F]-fluoro-3'-deoxy-3'-l-fluorothymidine ((18)F-FLT) PET. This manuscript reviews the rationale and physiology behind (18)F-FLT PET imaging, with special focus on pancreatic cancer and other gastrointestinal malignancies. Potential benefit and challenges of this imaging technique for diagnosis, staging and assessment of treatment response in abdominal malignancies are discussed.
    Citation
    (18)F-FLT PET imaging of cellular proliferation in pancreatic cancer. 2015: Crit Rev Oncol Hematol
    Journal
    Critical Reviews in Oncology/Hematology
    URI
    http://hdl.handle.net/10541/595566
    DOI
    10.1016/j.critrevonc.2015.12.014
    PubMed ID
    26778585
    Type
    Article
    Language
    en
    ISSN
    1879-0461
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.critrevonc.2015.12.014
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