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    Caveolin-3 promotes a vascular smooth muscle contractile phenotype.

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    Authors
    Gutierrez-Pajares, J
    Iturrieta, J
    Dulam, V
    Wang, Y
    Pavlides, Stephanos
    Malacari, G
    Lisanti, Michael P
    Frank, P
    Affiliation
    Faculte de Medecine, INSERM UMR1069 'Nutrition, Croissance et Cancer', Universite Francois Rabelais de Tours , Tours , France
    Issue Date
    2015
    
    Metadata
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    Abstract
    Epidemiological studies have demonstrated the importance of cardiovascular diseases in Western countries. Among the cell types associated with a dysfunctional vasculature, smooth muscle (SM) cells are believed to play an essential role in the development of these illnesses. Vascular SM cells are key regulators of the vascular tone and also have an important function in the development of atherosclerosis and restenosis. While in the normal vasculature, contractile SM cells are predominant, in atherosclerotic vascular lesions, synthetic cells migrate toward the neointima, proliferate, and synthetize extracellular matrix proteins. In the present study, we have examined the role of caveolin-3 in the regulation of SM cell phenotype. Caveolin-3 is expressed in vivo in normal arterial SM cells, but its expression appears to be lost in cultured SM cells. Our data show that caveolin-3 expression in the A7r5 SM cell line is associated with increased expression of contractility markers such as SM α-actin, SM myosin heavy chain but decreased expression of the synthetic phenotype markers such as p-Elk and Klf4. Moreover, we also show that caveolin-3 expression can reduce proliferation upon treatment with LDL or PDGF. Finally, we show that caveolin-3-expressing SM cells are less sensitive to apoptosis than control cells upon treatment with oxidized LDL. Taken together, our data suggest that caveolin-3 can regulate the phenotypic switch between contractile and synthetic SM cells. A better understanding of the factors regulating caveolin-3 expression and function in this cell type will permit the development of a better comprehension of the factors regulating SM function in atherosclerosis and restenosis.
    Citation
    Caveolin-3 Promotes a Vascular Smooth Muscle Contractile Phenotype. 2015, 2:27 Front Cardiovasc Med
    Journal
    Frontiers in Cardiovascular Medicine
    URI
    http://hdl.handle.net/10541/593321
    DOI
    10.3389/fcvm.2015.00027
    PubMed ID
    26664898
    Type
    Article
    Language
    en
    ISSN
    2297-055X
    ae974a485f413a2113503eed53cd6c53
    10.3389/fcvm.2015.00027
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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