• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Homozygous T172T and heterozygous G135C variants of homologous pecombination repairing protein RAD51 are pelated to sporadic breast cancer ousceptibility.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Al-Zoubi, M
    Mazzanti, C
    Zavaglia, K
    Hamad, M
    Armogida, I
    Lisanti, Michael P
    Bevilacqua, G
    Affiliation
    Division of Surgical, Molecular, and Ultrastructural Pathology, Pisa University Hospital, University of Pisa, Pisa, Italy
    Issue Date
    2015-12-09
    
    Metadata
    Show full item record
    Abstract
    Breast cancer (BC) is the most common cancer and the second leading cause of death among women worldwide. Only 10% of BC cases have been related to genetic predisposition. Rad51, a homologous recombination (HR) protein plays an important role in HR in meiosis and repairing DNA double-strand breaks. Expression of RAD51 may be a predictive biomarker in certain types of cancers. The exact mechanisms involved in the regulation of RAD51 expression are not fully understood, but certain transcription factors have been suggested to be the tuning mechanism of its expression. In this study, we propose that polymorphisms in the 5'-UTR promoter region of the RAD51 gene are prognostic factors for BC development. Direct sequencing of 106 samples from sporadic BC patients and 54 samples from a control group was performed. FFPE samples were the choice of sample collection, which might be a limitation of our study. Homologous variant T172T alone was found to be significantly associated with BC risk (OR 3.717, 95% CI 2.283-6.052, p < 0.0001). On the other hand, heterozygous G135C did not show any significant relationship with risk of sporadic BC (OR 1.598, 95% CI 0.5638-4.528, p > 0.05). Moreover, both variants; homozygous T172T and heterozygous G135C together; showed a significant relationship with sporadic BC susceptibility.
    Citation
    Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility. 2015: Biochem Genet
    Journal
    Biochemical Genetics
    URI
    http://hdl.handle.net/10541/593304
    DOI
    10.1007/s10528-015-9703-z
    PubMed ID
    26650628
    Type
    Article
    Language
    en
    ISSN
    1573-4927
    ae974a485f413a2113503eed53cd6c53
    10.1007/s10528-015-9703-z
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Single nucleotide polymorphisms of RAD51 G135C, XRCC2 Arg188His and XRCC3 Thr241Met homologous recombination repair genes and the risk of sporadic endometrial cancer in Polish women.
    • Authors: Romanowicz-Makowska H, Smolarz B, Połać I, Sporny S
    • Issue date: 2012 Jun
    • Polymorphic Variants in 5'-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC): A Case-Control Study.
    • Authors: Al Hamad M, Kussaibi H, Alkharsah KR, Alsayyah A, El Shawarby M, Al Tamimi D, Alomari M, Bakshi HA, Tambuwala MM, Al Zoubi MS
    • Issue date: 2021 Apr 1
    • Homologous recombination DNA repair gene RAD51, XRCC2 & XRCC3 polymorphisms and breast cancer risk in South Indian women.
    • Authors: Rajagopal T, Seshachalam A, Rathnam KK, Talluri S, Venkatabalasubramanian S, Dunna NR
    • Issue date: 2022
    • Combined effect of polymorphisms in Rad51 and Xrcc3 on breast cancer risk and chromosomal radiosensitivity.
    • Authors: Vral A, Willems P, Claes K, Poppe B, Perletti G, Thierens H
    • Issue date: 2011 Sep-Oct
    • Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility.
    • Authors: Ding SL, Yu JC, Chen ST, Hsu GC, Kuo SJ, Lin YH, Wu PE, Shen CY
    • Issue date: 2009 Jan
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.