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    microRNAs: An Emerging Paradigm in Lung Cancer Chemoresistance.

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    Authors
    Naidu, Srivatsava
    Garofalo, Michela
    Affiliation
    Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester , Manchester
    Issue Date
    2015
    
    Metadata
    Show full item record
    Abstract
    Lung cancer is considered the most deadly of all cancers, with limited therapeutic options. Although advanced drugs have been tried in clinic, the therapeutic success has largely been hampered due to rapid development of drug-resistance mechanisms. Recently, microRNAs (miRNAs), a class of small non-coding RNAs, have occupied center stage in cancer biology. miRNAs negatively regulate gene expression either by promoting degradation or by interfering with translation of messenger RNA targets. Several lines of evidence have confirmed the crucial role of miRNAs in carcinogenesis, and, importantly, in the acquisition of resistance to chemotherapeutics. Modulation of miRNA expression levels has been proven to increase the efficacy of genotoxic drugs in various preclinical cancer studies. Therefore, comprehensive understanding of the role(s) of these key players in drug resistance may provide novel opportunities to design effective combinatorial therapeutic strategies for cancer treatment. In this review, we highlight recent findings on miRNAs acting as oncomiRs and tumor suppressor genes in lung cancer. Moreover, we discuss the involvement of miRNAs in different mechanisms of drug resistance in this deadly disease.
    Citation
    microRNAs: An Emerging Paradigm in Lung Cancer Chemoresistance. 2015, 2:77 Front Med
    Journal
    Frontiers in Medicine
    URI
    http://hdl.handle.net/10541/592958
    DOI
    10.3389/fmed.2015.00077
    PubMed ID
    26583081
    Type
    Article
    Language
    en
    ISSN
    2296-858X
    ae974a485f413a2113503eed53cd6c53
    10.3389/fmed.2015.00077
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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