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    DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.

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    Authors
    Mateo, J
    Carreira, S
    Sandhu, S
    Miranda, S
    Mossop, H
    Perez-Lopez, R
    Nava Rodrigues, D
    Robinson, D
    Omlin, A
    Tunariu, N
    Boysen, G
    Porta, N
    Flohr, P
    Gillman, A
    Figueiredo, I
    Paulding, C
    Seed, G
    Jain, S
    Ralph, C
    Protheroe, A
    Hussain, S
    Jones, R
    Elliott, Tony
    McGovern, U
    Bianchini, D
    Goodall, J
    Zafeiriou, Z
    Williamson, C
    Ferraldeschi, R
    Riisnaes, R
    Ebbs, B
    Fowler, G
    Roda, D
    Yuan, W
    Wu, Y
    Cao, X
    Brough, R
    Pemberton, H
    A'Hern, R
    Swain, A
    Kunju, L
    Eeles, R
    Attard, G
    Lord, C
    Ashworth, A
    Rubin, M
    Knudsen, K
    Feng, F
    Chinnaiyan, A
    Hall, E
    de Bono, J
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    Affiliation
    Institute of Cancer Research, London
    Issue Date
    2015-10-29
    
    Metadata
    Show full item record
    Abstract
    Prostate cancer is a heterogeneous disease, but current treatments are not based on molecular stratification. We hypothesized that metastatic, castration-resistant prostate cancers with DNA-repair defects would respond to poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibition with olaparib.
    Citation
    DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. 2015, 373 (18):1697-708 N Engl J Med
    Journal
    The New England Journal of Medicine
    URI
    http://hdl.handle.net/10541/592954
    DOI
    10.1056/NEJMoa1506859
    PubMed ID
    26510020
    Type
    Article
    Language
    en
    ISSN
    1533-4406
    ae974a485f413a2113503eed53cd6c53
    10.1056/NEJMoa1506859
    Scopus Count
    Collections
    All Christie Publications

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