Fluorouracil plasma monitoring: systematic review and economic evaluation of the My5-FU assay for guiding dose adjustment in patients receiving fluorouracil chemotherapy by continuous infusion.
Authors
Freeman, KConnock, M
Cummins, E
Gurung, T
Taylor-Phillips, S
Court, R
Saunders, Mark P
Clarke, A
Sutcliffe, P
Affiliation
Warwick Medical School, University of Warwick, CoventryIssue Date
2015-11
Metadata
Show full item recordAbstract
5-Fluorouracil (5-FU) is a chemotherapy used in colorectal, head and neck (H&N) and other cancers. Dose adjustment is based on body surface area (BSA) but wide variations occur. Pharmacokinetic (PK) dosing is suggested to bring plasma levels into the therapeutic range to promote fewer side effects and better patient outcomes. We investigated the clinical effectiveness and cost-effectiveness of the My5-FU assay for PK dose adjustment to 5-FU therapy.Citation
Fluorouracil plasma monitoring: systematic review and economic evaluation of the My5-FU assay for guiding dose adjustment in patients receiving fluorouracil chemotherapy by continuous infusion. 2015, 19 (91):1-322 Health Technol AssessJournal
Health Technology AssessmentDOI
10.3310/hta19910PubMed ID
26542268Type
ArticleLanguage
enISSN
2046-4924ae974a485f413a2113503eed53cd6c53
10.3310/hta19910
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