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    Fluorouracil plasma monitoring: systematic review and economic evaluation of the My5-FU assay for guiding dose adjustment in patients receiving fluorouracil chemotherapy by continuous infusion.

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    Authors
    Freeman, K
    Connock, M
    Cummins, E
    Gurung, T
    Taylor-Phillips, S
    Court, R
    Saunders, Mark P
    Clarke, A
    Sutcliffe, P
    Affiliation
    Warwick Medical School, University of Warwick, Coventry
    Issue Date
    2015-11
    
    Metadata
    Show full item record
    Abstract
    5-Fluorouracil (5-FU) is a chemotherapy used in colorectal, head and neck (H&N) and other cancers. Dose adjustment is based on body surface area (BSA) but wide variations occur. Pharmacokinetic (PK) dosing is suggested to bring plasma levels into the therapeutic range to promote fewer side effects and better patient outcomes. We investigated the clinical effectiveness and cost-effectiveness of the My5-FU assay for PK dose adjustment to 5-FU therapy.
    Citation
    Fluorouracil plasma monitoring: systematic review and economic evaluation of the My5-FU assay for guiding dose adjustment in patients receiving fluorouracil chemotherapy by continuous infusion. 2015, 19 (91):1-322 Health Technol Assess
    Journal
    Health Technology Assessment
    URI
    http://hdl.handle.net/10541/592937
    DOI
    10.3310/hta19910
    PubMed ID
    26542268
    Type
    Article
    Language
    en
    ISSN
    2046-4924
    ae974a485f413a2113503eed53cd6c53
    10.3310/hta19910
    Scopus Count
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    All Christie Publications

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