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    Management of unresectable stage III non-small-cell lung cancer with combined-modality therapy: a review of the current literature and recommendations for treatment.

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    Authors
    Bayman, Neil A
    Blackhall, Fiona H
    Jain, Pooja
    Lee, Lip W
    Thatcher, Nick
    Faivre-Finn, Corinne
    Affiliation
    Department of Clinical Oncology, Christie Hospital, Manchester, UK. neil.bayman@christie.nhs.uk
    Issue Date
    2008-03
    
    Metadata
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    Abstract
    Lung cancer remains the most common cause of cancer deaths in the United Kingdom, and long-term survival from lung cancer has hardly improved over the past 30 years. The benefit of combined-modality therapy with chemotherapy and radiation therapy in improving survival for patients with inoperable non-small-cell lung cancer (NSCLC) was discovered over 10 years ago. In this comprehensive literature review, we discuss the current status of combined-modality therapy for unresectable stage III NSCLC. The efficacy and toxicity of different chemoradiation therapy regimens are presented. The potential role of novel and targeted therapies and radiation dose escalation is also considered. Finally, recommendations are made for the treatment of unresectable stage III NSCLC.
    Citation
    Management of unresectable stage III non-small-cell lung cancer with combined-modality therapy: a review of the current literature and recommendations for treatment. 2008, 9 (2):92-101 Clin Lung Cancer
    Journal
    Clinical Lung Cancer
    URI
    http://hdl.handle.net/10541/58717
    DOI
    10.3816/CLC.2008.n.014
    PubMed ID
    18501095
    Type
    Article
    Language
    en
    ISSN
    1525-7304
    ae974a485f413a2113503eed53cd6c53
    10.3816/CLC.2008.n.014
    Scopus Count
    Collections
    All Christie Publications
    Medical Oncology
    Clinical Oncology

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