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    Estimation of renal function -- what is appropriate in cancer patients?

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    Authors
    Barraclough, Lisa H
    Field, Catherine
    Wieringa, Gilbert E
    Swindell, Ric
    Livsey, Jacqueline E
    Davidson, Susan E
    Affiliation
    Department of Clinical Oncology, Christie Hospital, Manchester, UK. lisahelenbone@hotmail.com
    Issue Date
    2008-12
    
    Metadata
    Show full item record
    Abstract
    AIMS: To compare the accuracy of renal assessment in patients with cancer using radioisotope glomerular filtration rate (GFR), urine collection for creatinine clearance, Cockroft-Gault, Modification of Diet in Renal Disease (MDRD) and Wright formulae. MATERIALS AND METHODS: Measurements of isotope GFR from 367 patients were compared with estimates from the described methods (Cockroft-Gault, MDRD, Wright). An analysis including a further 252 patients with an isotope GFR < or = 50 ml/min was also carried out. RESULTS: The Wright formula was the most accurate form of estimating renal function for the first study group. The formulae were similar in accuracy in the second study group. CONCLUSIONS: The Wright formula is the most accurate form of estimation of renal function in comparison with the isotope GFR for cancer patients. When there is a large proportion of patients with a low isotope GFR (< or = 50 ml/min), the formulae have similar accuracy.
    Citation
    Estimation of renal function -- what is appropriate in cancer patients? 2008, 20 (10):721-6 Clin Oncol (R Coll Radiol)
    Journal
    Clinical Oncology
    URI
    http://hdl.handle.net/10541/58715
    DOI
    10.1016/j.clon.2008.09.004
    PubMed ID
    18995170
    Type
    Article
    Language
    en
    ISSN
    0936-6555
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clon.2008.09.004
    Scopus Count
    Collections
    All Christie Publications
    Pathology
    Clinical Oncology

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