Estimation of renal function -- what is appropriate in cancer patients?
AuthorsBarraclough, Lisa H
Wieringa, Gilbert E
Livsey, Jacqueline E
Davidson, Susan E
AffiliationDepartment of Clinical Oncology, Christie Hospital, Manchester, UK. email@example.com
MetadataShow full item record
AbstractAIMS: To compare the accuracy of renal assessment in patients with cancer using radioisotope glomerular filtration rate (GFR), urine collection for creatinine clearance, Cockroft-Gault, Modification of Diet in Renal Disease (MDRD) and Wright formulae. MATERIALS AND METHODS: Measurements of isotope GFR from 367 patients were compared with estimates from the described methods (Cockroft-Gault, MDRD, Wright). An analysis including a further 252 patients with an isotope GFR < or = 50 ml/min was also carried out. RESULTS: The Wright formula was the most accurate form of estimating renal function for the first study group. The formulae were similar in accuracy in the second study group. CONCLUSIONS: The Wright formula is the most accurate form of estimation of renal function in comparison with the isotope GFR for cancer patients. When there is a large proportion of patients with a low isotope GFR (< or = 50 ml/min), the formulae have similar accuracy.
CitationEstimation of renal function -- what is appropriate in cancer patients? 2008, 20 (10):721-6 Clin Oncol (R Coll Radiol)