External beam boost for cancer of the cervix uteri when intracavitary therapy cannot be performed.
AffiliationDepartment of Clinical Oncology, Christie Hospital, Manchester, UK. firstname.lastname@example.org
MetadataShow full item record
AbstractPURPOSE: To assess the outcome of patients treated with radical radiotherapy for cervical cancer who received an external beam boost, in place of intracavitary brachytherapy (ICT), after irradiation to the whole pelvis. METHODS AND MATERIALS: Case notes were reviewed for all patients treated in this way in a single center between 1996 and 2004. Patient and tumor details, the reasons why ICT was not possible, and treatment outcome were documented. RESULTS: Forty-four patients were identified. The mean age was 56.4 years (range, 26-88 years). Clinical International Federation of Gynecology and Obstetrics or radiologic stage for Stages I, II, III, and IV, respectively, was 16%, 48%, 27%, and 7%. A total radiation dose of 54-70 Gy was given (75% received > or =60 Gy). Reasons for ICT not being performed were technical limitations in 73%, comorbidity or isolation limitations in 23%, and patient choice in 4%. The median follow-up was 2.3 years. Recurrent disease was seen in 48%, with a median time to recurrence of 2.3 years. Central recurrence was seen in 16 of the 21 patients with recurrent disease. The 5-year overall survival rate was 49.3%. The 3-year cancer-specific survival rate by stage was 100%, 70%, and 42% for Stages I, II, and III, respectively. Late Grades 1 and 2 bowel, bladder, and vaginal toxicity were seen in 41%. Late Grade 3 toxicity was seen in 2%. CONCLUSION: An external beam boost is a reasonable option after external beam radiotherapy to the pelvis when it is not possible to perform ICT.
CitationExternal beam boost for cancer of the cervix uteri when intracavitary therapy cannot be performed. 2008, 71 (3):772-8 Int. J. Radiat. Oncol. Biol. Phys.
JournalInternational Journal of Radiation Oncology, Biology, Physics
- High-dose-rate interstitial brachytherapy for gynecologic malignancies.
- Authors: Beriwal S, Bhatnagar A, Heron DE, Selvaraj R, Mogus R, Kim H, Gerszten K, Kelley J, Edwards RP
- Issue date: 2006 Oct-Dec
- High-dose-rate brachytherapy in uterine cervical carcinoma.
- Authors: Patel FD, Rai B, Mallick I, Sharma SC
- Issue date: 2005 May 1
- Radical radiotherapy with high-dose-rate brachytherapy for uterine cervix cancer long-term results.
- Authors: Khor TH, Tuan JK, Hee SW, Tham IW
- Issue date: 2007 Dec
- Radiation therapy alone in stage III-B cancer of the uterine cervix--a 17-year old experience in southern Brazil.
- Authors: Ferreira PR, Braga-Filho A, Barletta A, Ilha LA
- Issue date: 1999 Sep 1
- Radiotherapy alone in the treatment of uterine cervix cancer with telecobalt and low-dose-rate brachytherapy: retrospective analysis of results and variables.
- Authors: Ferrigno R, Campos de Oliveira Faria SL, Weltman E, Salvajoli JV, Segreto RA, Pastore A, Nadalin W
- Issue date: 2003 Mar 1