Systematic reviews and meta-analyses in coloproctology: interpretation and potential pitfalls.
AffiliationDepartment of Surgery K, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark. firstname.lastname@example.org
MetadataShow full item record
AbstractA systematic review (SR) is the unbiased appraisal of systematically identified relevant studies. Implicit in its definition is a robust and scientifically valid process, and when performed as such, SR is an important clinical research tool and influence in health policy decision-making. This educational paper outlines that, from the original prototype based on randomized trials, there are now many other types of SRs including those based on: nonrandomized comparative studies, observational studies, prognostic studies, and studies of diagnostic and screening tools. While each of these has a similar 'anatomy' or format, at an individual class level, there are principles specific to each SR type. Several examples from the coloproctology literature are used as case-studies to illustrate potential pitfalls, and upon re-analysis, often reverse or attenuate the conclusions stated in the original publication. These examples serve to emphasize the need for health professionals to understand the process of SR and meta-analysis so that we all arrive at appropriate interpretations to the benefit of our patients.
CitationSystematic reviews and meta-analyses in coloproctology: interpretation and potential pitfalls. 2008, 10 (1):21-32 Colorectal Dis
- 7th Biennial Congress of the Mediterranean Society of Coloproctology (MSCP), Thessaloniki, Greece, April 22-24, 2010.
- Authors: Yiannakopoulou E
- Issue date: 2010 Sep
- [The impact of minimally invasive techniques in colorectal surgery].
- Authors: Oviedo MR, Wexner SD
- Issue date: 2008 Oct
- Evidence Corner: Improving Outcomes of Colorectal Surgery.
- Authors: Bolton L
- Issue date: 2015 Oct
- Evidence-based medicine, systematic reviews, and guidelines in interventional pain management: part 6. Systematic reviews and meta-analyses of observational studies.
- Authors: Manchikanti L, Datta S, Smith HS, Hirsch JA
- Issue date: 2009 Sep-Oct
- Systematic reviews and meta-analyses of randomized trials: principles and pitfalls.
- Authors: da Costa BR, Juni P
- Issue date: 2014 Dec 14