Childhood leukaemia: long-term excess mortality and the proportion 'cured'.
AffiliationNon-communicable Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. email@example.com
MetadataShow full item record
AbstractSurvival from childhood leukaemia has increased, but the proportion of children cured is unknown. The proportion 'cured' is defined as the proportion of survivors for whom, as a group, there is no longer excess mortality compared to the general population. Average time to cure is defined as the time since diagnosis at which the excess mortality rate has declined to or below a predetermined small value. Data on children diagnosed with leukaemia during 1971-2000 in Great Britain were used to estimate trends in survival, the proportion cured and the average time to cure. Five-year survival for all types of leukaemia combined rose from 33 to 79% by 2000. The percentage cured rose from 25 to 68% by 1995; it is predicted to increase to 73% for those diagnosed more recently. Average time to cure increased from 12 years (95% confidence interval (CI): 11-14) to 19 years (95% CI: 14-26) for lymphoid leukaemia (average annual increase of 0.3 years; P<0.001), but remained at about 5 years for acute nonlymphoblastic leukaemia. The proportion of children cured of leukaemia has risen dramatically, but the period of excess mortality associated with lymphoid leukaemia has also increased, possibly because of late relapse, secondary malignancy and toxicity from treatment.
CitationChildhood leukaemia: long-term excess mortality and the proportion 'cured'. 2008, 99 (1):219-23 Br. J. Cancer
JournalBritish Journal of Cancer
- Italian cancer figures, report 2012: Cancer in children and adolescents.
- Authors: AIRTUM Working Group, CCM, AIEOP Working Group
- Issue date: 2013 Jan-Feb
- Survival and cure of acute myeloid leukaemia in England, 1971-2006: a population-based study.
- Authors: Shah A, Andersson TM, Rachet B, Björkholm M, Lambert PC
- Issue date: 2013 Aug
- Long-term survival after childhood acute lymphoblastic leukaemia: population-based trends in cure and relapse by clinical characteristics.
- Authors: Smith L, Glaser AW, Kinsey SE, Greenwood DC, Chilton L, Moorman AV, Feltbower RG
- Issue date: 2018 Sep
- Italian cancer figures, report 2014: Prevalence and cure of cancer in Italy.
- Authors: AIRTUM Working Group
- Issue date: 2014 Nov-Dec
- Worldwide comparison of survival from childhood leukaemia for 1995-2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries.
- Authors: Bonaventure A, Harewood R, Stiller CA, Gatta G, Clavel J, Stefan DC, Carreira H, Spika D, Marcos-Gragera R, Peris-Bonet R, Piñeros M, Sant M, Kuehni CE, Murphy MFG, Coleman MP, Allemani C, CONCORD Working Group
- Issue date: 2017 May