The psychosocial impact of human papillomavirus testing in primary cervical screening-a study within a randomized trial.
dc.contributor.author | Kitchener, Henry C | |
dc.contributor.author | Fletcher, I | |
dc.contributor.author | Roberts, Caleb | |
dc.contributor.author | Wheeler, P | |
dc.contributor.author | Almonte, M | |
dc.contributor.author | Maguire, Peter | |
dc.date.accessioned | 2009-04-01T22:53:34Z | |
dc.date.available | 2009-04-01T22:53:34Z | |
dc.date.issued | 2009-04-01T22:53:34Z | |
dc.identifier.citation | The psychosocial impact of human papillomavirus testing in primary cervical screening-a study within a randomized trial., 18 (4):743-8 Int. J. Gynecol. Cancer | en |
dc.identifier.issn | 1525-1438 | |
dc.identifier.pmid | 17944916 | |
dc.identifier.doi | 10.1111/j.1525-1438.2007.01113.x | |
dc.identifier.uri | http://hdl.handle.net/10541/58676 | |
dc.description.abstract | The purpose of the study was to assess the psychosocial impact of human papillomavirus (HPV) testing as an adjunct to cytology in routine primary cervical screening. A controlled study of the psychosocial impact of HPV testing within a randomized trial of HPV testing to assess its efficacy in cervical screening was carried out. The trial provides a randomized setting of revealed HPV results versus concealed results permitting valid comparisons for assessing true psychosocial impact. The setting comprised a large number of general practices in primary care. Women aged 20-64 years who underwent routine cervical screening participated in the study. The intervention was a revealed high-risk HPV test result in addition to cervical cytology. The main outcome was measured using General Health Questionnaire (GHQ-28), Spielberger State-Trait Anxiety Inventory, and Sexual Rating Scale (SRS). Among women with either mildly abnormal or normal cytology, receiving an HPV(+ve) result did not impact significantly on GHQ caseness and mean scores or on Spielberger State and Trait scores when compared with women in whom the HPV(+ve) test result was concealed. Among women with normal cytology, receiving an HPV(+ve) result was associated with a reduction in the Sexual Rating Scale compared with similar women whose HPV(+ve) result was concealed. HPV testing does not add significant psychologic distress when combined with cytology in routine primary cervical screening. | |
dc.language.iso | en | en |
dc.subject | Human Papillomavirus | en |
dc.subject | Cervical Screening | en |
dc.subject | HPV | en |
dc.subject.mesh | Adult | |
dc.subject.mesh | Alphapapillomavirus | |
dc.subject.mesh | Cervical Intraepithelial Neoplasia | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Mass Screening | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Papillomavirus Infections | |
dc.subject.mesh | Precancerous Conditions | |
dc.subject.mesh | Prognosis | |
dc.subject.mesh | Questionnaires | |
dc.subject.mesh | Randomized Controlled Trials as Topic | |
dc.subject.mesh | Uterine Cervical Neoplasms | |
dc.subject.mesh | Vaginal Smears | |
dc.title | The psychosocial impact of human papillomavirus testing in primary cervical screening-a study within a randomized trial. | en |
dc.type | Article | en |
dc.contributor.department | Division of Human Development, Academic Unit of Obstetrics and Gynaecology, University of Manchester, Manchester, United Kingdom. henry.kitchener@cmmc.nhs.uk | en |
dc.identifier.journal | International Journal of Gynecological Cancer | en |
html.description.abstract | The purpose of the study was to assess the psychosocial impact of human papillomavirus (HPV) testing as an adjunct to cytology in routine primary cervical screening. A controlled study of the psychosocial impact of HPV testing within a randomized trial of HPV testing to assess its efficacy in cervical screening was carried out. The trial provides a randomized setting of revealed HPV results versus concealed results permitting valid comparisons for assessing true psychosocial impact. The setting comprised a large number of general practices in primary care. Women aged 20-64 years who underwent routine cervical screening participated in the study. The intervention was a revealed high-risk HPV test result in addition to cervical cytology. The main outcome was measured using General Health Questionnaire (GHQ-28), Spielberger State-Trait Anxiety Inventory, and Sexual Rating Scale (SRS). Among women with either mildly abnormal or normal cytology, receiving an HPV(+ve) result did not impact significantly on GHQ caseness and mean scores or on Spielberger State and Trait scores when compared with women in whom the HPV(+ve) test result was concealed. Among women with normal cytology, receiving an HPV(+ve) result was associated with a reduction in the Sexual Rating Scale compared with similar women whose HPV(+ve) result was concealed. HPV testing does not add significant psychologic distress when combined with cytology in routine primary cervical screening. |