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dc.contributor.authorKitchener, Henry C
dc.contributor.authorFletcher, I
dc.contributor.authorRoberts, Caleb
dc.contributor.authorWheeler, P
dc.contributor.authorAlmonte, M
dc.contributor.authorMaguire, Peter
dc.date.accessioned2009-04-01T22:53:34Z
dc.date.available2009-04-01T22:53:34Z
dc.date.issued2009-04-01T22:53:34Z
dc.identifier.citationThe psychosocial impact of human papillomavirus testing in primary cervical screening-a study within a randomized trial., 18 (4):743-8 Int. J. Gynecol. Canceren
dc.identifier.issn1525-1438
dc.identifier.pmid17944916
dc.identifier.doi10.1111/j.1525-1438.2007.01113.x
dc.identifier.urihttp://hdl.handle.net/10541/58676
dc.description.abstractThe purpose of the study was to assess the psychosocial impact of human papillomavirus (HPV) testing as an adjunct to cytology in routine primary cervical screening. A controlled study of the psychosocial impact of HPV testing within a randomized trial of HPV testing to assess its efficacy in cervical screening was carried out. The trial provides a randomized setting of revealed HPV results versus concealed results permitting valid comparisons for assessing true psychosocial impact. The setting comprised a large number of general practices in primary care. Women aged 20-64 years who underwent routine cervical screening participated in the study. The intervention was a revealed high-risk HPV test result in addition to cervical cytology. The main outcome was measured using General Health Questionnaire (GHQ-28), Spielberger State-Trait Anxiety Inventory, and Sexual Rating Scale (SRS). Among women with either mildly abnormal or normal cytology, receiving an HPV(+ve) result did not impact significantly on GHQ caseness and mean scores or on Spielberger State and Trait scores when compared with women in whom the HPV(+ve) test result was concealed. Among women with normal cytology, receiving an HPV(+ve) result was associated with a reduction in the Sexual Rating Scale compared with similar women whose HPV(+ve) result was concealed. HPV testing does not add significant psychologic distress when combined with cytology in routine primary cervical screening.
dc.language.isoenen
dc.subjectHuman Papillomavirusen
dc.subjectCervical Screeningen
dc.subjectHPVen
dc.subject.meshAdult
dc.subject.meshAlphapapillomavirus
dc.subject.meshCervical Intraepithelial Neoplasia
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMass Screening
dc.subject.meshMiddle Aged
dc.subject.meshPapillomavirus Infections
dc.subject.meshPrecancerous Conditions
dc.subject.meshPrognosis
dc.subject.meshQuestionnaires
dc.subject.meshRandomized Controlled Trials as Topic
dc.subject.meshUterine Cervical Neoplasms
dc.subject.meshVaginal Smears
dc.titleThe psychosocial impact of human papillomavirus testing in primary cervical screening-a study within a randomized trial.en
dc.typeArticleen
dc.contributor.departmentDivision of Human Development, Academic Unit of Obstetrics and Gynaecology, University of Manchester, Manchester, United Kingdom. henry.kitchener@cmmc.nhs.uken
dc.identifier.journalInternational Journal of Gynecological Canceren
html.description.abstractThe purpose of the study was to assess the psychosocial impact of human papillomavirus (HPV) testing as an adjunct to cytology in routine primary cervical screening. A controlled study of the psychosocial impact of HPV testing within a randomized trial of HPV testing to assess its efficacy in cervical screening was carried out. The trial provides a randomized setting of revealed HPV results versus concealed results permitting valid comparisons for assessing true psychosocial impact. The setting comprised a large number of general practices in primary care. Women aged 20-64 years who underwent routine cervical screening participated in the study. The intervention was a revealed high-risk HPV test result in addition to cervical cytology. The main outcome was measured using General Health Questionnaire (GHQ-28), Spielberger State-Trait Anxiety Inventory, and Sexual Rating Scale (SRS). Among women with either mildly abnormal or normal cytology, receiving an HPV(+ve) result did not impact significantly on GHQ caseness and mean scores or on Spielberger State and Trait scores when compared with women in whom the HPV(+ve) test result was concealed. Among women with normal cytology, receiving an HPV(+ve) result was associated with a reduction in the Sexual Rating Scale compared with similar women whose HPV(+ve) result was concealed. HPV testing does not add significant psychologic distress when combined with cytology in routine primary cervical screening.


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