The psychosocial impact of human papillomavirus testing in primary cervical screening-a study within a randomized trial.
AffiliationDivision of Human Development, Academic Unit of Obstetrics and Gynaecology, University of Manchester, Manchester, United Kingdom. firstname.lastname@example.org
MetadataShow full item record
AbstractThe purpose of the study was to assess the psychosocial impact of human papillomavirus (HPV) testing as an adjunct to cytology in routine primary cervical screening. A controlled study of the psychosocial impact of HPV testing within a randomized trial of HPV testing to assess its efficacy in cervical screening was carried out. The trial provides a randomized setting of revealed HPV results versus concealed results permitting valid comparisons for assessing true psychosocial impact. The setting comprised a large number of general practices in primary care. Women aged 20-64 years who underwent routine cervical screening participated in the study. The intervention was a revealed high-risk HPV test result in addition to cervical cytology. The main outcome was measured using General Health Questionnaire (GHQ-28), Spielberger State-Trait Anxiety Inventory, and Sexual Rating Scale (SRS). Among women with either mildly abnormal or normal cytology, receiving an HPV(+ve) result did not impact significantly on GHQ caseness and mean scores or on Spielberger State and Trait scores when compared with women in whom the HPV(+ve) test result was concealed. Among women with normal cytology, receiving an HPV(+ve) result was associated with a reduction in the Sexual Rating Scale compared with similar women whose HPV(+ve) result was concealed. HPV testing does not add significant psychologic distress when combined with cytology in routine primary cervical screening.
CitationThe psychosocial impact of human papillomavirus testing in primary cervical screening-a study within a randomized trial., 18 (4):743-8 Int. J. Gynecol. Cancer
JournalInternational Journal of Gynecological Cancer
- 'I don't care whether it's HPV or ABC, I just want to know if I have cancer.' Factors influencing women's emotional responses to undergoing human papillomavirus testing in routine management in cervical screening: a qualitative study.
- Authors: O'Connor M, Costello L, Murphy J, Prendiville W, Martin CM, O'Leary JJ, Sharp L, Irish Screening Research Consortium (CERVIVA).
- Issue date: 2014 Oct
- ARTISTIC: a randomised trial of human papillomavirus (HPV) testing in primary cervical screening.
- Authors: Kitchener HC, Almonte M, Gilham C, Dowie R, Stoykova B, Sargent A, Roberts C, Desai M, Peto J, ARTISTIC Trial Study Group.
- Issue date: 2009 Nov
- The clinical effectiveness and cost-effectiveness of primary human papillomavirus cervical screening in England: extended follow-up of the ARTISTIC randomised trial cohort through three screening rounds.
- Authors: C Kitchener H, Canfell K, Gilham C, Sargent A, Roberts C, Desai M, Peto J
- Issue date: 2014 Apr
- Testing positive for human papillomavirus in routine cervical screening: examination of psychosocial impact.
- Authors: McCaffery K, Waller J, Forrest S, Cadman L, Szarewski A, Wardle J
- Issue date: 2004 Dec
- Results at recruitment from a randomized controlled trial comparing human papillomavirus testing alone with conventional cytology as the primary cervical cancer screening test.
- Authors: Ronco G, Giorgi-Rossi P, Carozzi F, Confortini M, Dalla Palma P, Del Mistro A, Gillio-Tos A, Minucci D, Naldoni C, Rizzolo R, Schincaglia P, Volante R, Zappa M, Zorzi M, Cuzick J, Segnan N, New Technologies for Cervical Cancer Screening Working Group.
- Issue date: 2008 Apr 2