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    FOXM1 and polo-like kinase 1 are co-ordinately overexpressed in patients with gastric adenocarcinomas.

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    Authors
    Dibb, M
    Han, N
    Choudhury, J
    Hayes, S
    Valentine, Helen R
    West, Catharine M L
    Sharrocks, A
    Ang, Y
    Affiliation
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT
    Issue Date
    2015
    
    Metadata
    Show full item record
    Abstract
    Gastric cancers present late in life with advanced disease and carry a poor prognosis. Polo-like Kinase 1 (PLK1) is a mitotic kinase with regulatory functions during G2/M and mitosis in the cell cycle. In mammalian cells, there is an intricate co-regulatory relationship between PLK1 and the forkhead transcription factor FOXM1. It has been demonstrated that individually either PLK1 or FOXM1 expression predicts poorer survival. However, the co-expression of both of these markers in gastric adenocarcinomas has not been reported previously.
    Citation
    FOXM1 and polo-like kinase 1 are co-ordinately overexpressed in patients with gastric adenocarcinomas. 2015, 8:676 BMC Res Notes
    Journal
    BMC Research Notes
    URI
    http://hdl.handle.net/10541/583613
    DOI
    10.1186/s13104-015-1658-y
    PubMed ID
    26576650
    Type
    Article
    Language
    en
    ISSN
    1756-0500
    ae974a485f413a2113503eed53cd6c53
    10.1186/s13104-015-1658-y
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