The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer.
Authors
Wang, NReeves, Kimberley J
Brown, H
Fowles, A
Docherty, F
Ottewell, P
Croucher, P
Holen, I
Eaton, C
Affiliation
The Mellanby Centre for Bone Research, Department of Human Metabolism, Medical School, University of Sheffield, Beech Hill Road, Sheffield, S10 2RXIssue Date
2015
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While both preclinical and clinical studies suggest that the frequency of growing skeletal metastases is elevated in individuals with higher bone turnover, it is unclear whether this is a result of increased numbers of tumour cells arriving in active sites or of higher numbers of tumour cells being induced to divide by the bone micro-environment. Here we have investigated how the differences in bone turnover affect seeding of tumour cells and/or development of overt osteolytic bone metastasis using in vivo models of hormone-independent breast and prostate cancer.Citation
The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer. 2015, 34 (1):124 J Exp Clin Cancer ResJournal
Journal of Experimental & Clinical Cancer ResearchDOI
10.1186/s13046-015-0240-8PubMed ID
26480944Type
ArticleLanguage
enISSN
1756-9966ae974a485f413a2113503eed53cd6c53
10.1186/s13046-015-0240-8
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