The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer.
Authors
Wang, NReeves, Kimberley J
Brown, H
Fowles, A
Docherty, F
Ottewell, P
Croucher, P
Holen, I
Eaton, C
Affiliation
The Mellanby Centre for Bone Research, Department of Human Metabolism, Medical School, University of Sheffield, Beech Hill Road, Sheffield, S10 2RXIssue Date
2015
Metadata
Show full item recordAbstract
While both preclinical and clinical studies suggest that the frequency of growing skeletal metastases is elevated in individuals with higher bone turnover, it is unclear whether this is a result of increased numbers of tumour cells arriving in active sites or of higher numbers of tumour cells being induced to divide by the bone micro-environment. Here we have investigated how the differences in bone turnover affect seeding of tumour cells and/or development of overt osteolytic bone metastasis using in vivo models of hormone-independent breast and prostate cancer.Citation
The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer. 2015, 34 (1):124 J Exp Clin Cancer ResJournal
Journal of Experimental & Clinical Cancer ResearchDOI
10.1186/s13046-015-0240-8PubMed ID
26480944Type
ArticleLanguage
enISSN
1756-9966ae974a485f413a2113503eed53cd6c53
10.1186/s13046-015-0240-8