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    The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer.

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    Authors
    Wang, N
    Reeves, Kimberley J
    Brown, H
    Fowles, A
    Docherty, F
    Ottewell, P
    Croucher, P
    Holen, I
    Eaton, C
    Affiliation
    The Mellanby Centre for Bone Research, Department of Human Metabolism, Medical School, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX
    Issue Date
    2015
    
    Metadata
    Show full item record
    Abstract
    While both preclinical and clinical studies suggest that the frequency of growing skeletal metastases is elevated in individuals with higher bone turnover, it is unclear whether this is a result of increased numbers of tumour cells arriving in active sites or of higher numbers of tumour cells being induced to divide by the bone micro-environment. Here we have investigated how the differences in bone turnover affect seeding of tumour cells and/or development of overt osteolytic bone metastasis using in vivo models of hormone-independent breast and prostate cancer.
    Citation
    The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer. 2015, 34 (1):124 J Exp Clin Cancer Res
    Journal
    Journal of Experimental & Clinical Cancer Research
    URI
    http://hdl.handle.net/10541/583216
    DOI
    10.1186/s13046-015-0240-8
    PubMed ID
    26480944
    Type
    Article
    Language
    en
    ISSN
    1756-9966
    ae974a485f413a2113503eed53cd6c53
    10.1186/s13046-015-0240-8
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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