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    Intranasal human growth hormone (hGH) induces IGF-I levels comparable to subcutaneous injection with lower systemic exposure to hGH in healthy volunteers.

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    Authors
    Lewis, A
    Jordan, F
    Patel, T
    Jeffery, K
    King, G
    Savage, M
    Shalet, Stephen M
    Illum, L
    Affiliation
    Critical Pharmaceuticals Limited, BioCity Nottingham, Pennyfoot St, Nottingham
    Issue Date
    2015-10-01
    
    Metadata
    Show full item record
    Abstract
    The development of an improved, efficacious hGH product administered by a non-injectable route of delivery such as the nasal route is highly desirable. We have developed a novel nasal hGH product (CP024) that showed excellent nasal absorption in animal models, however translation of these results into the clinical setting is essential, as past attempts to develop such formulations by other groups have been unable to induce IGF-1 in man.
    Citation
    Intranasal human growth hormone (hGH) induces IGF-I levels comparable to subcutaneous injection with lower systemic exposure to hGH in healthy volunteers. 2015:jc20144146 J Clin Endocrinol Metab
    Journal
    Journal of Clinical Endocrinology and Metabolism
    URI
    http://hdl.handle.net/10541/582534
    DOI
    10.1210/jc.2014-4146
    PubMed ID
    26425883
    Type
    Article
    Language
    en
    ISSN
    1945-7197
    ae974a485f413a2113503eed53cd6c53
    10.1210/jc.2014-4146
    Scopus Count
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