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    LungTech, an EORTC Phase II trial of stereotactic body radiotherapy for centrally located lung tumours: a clinical perspective.

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    Authors
    Adebahr, S
    Collette, S
    Shash, E
    Lambrecht, M
    Le Pechoux, C
    Faivre-Finn, Corinne
    De Ruysscher, D
    Peulen, H
    Belderbos, J
    Dziadziuszko, R
    Fink, C
    Guckenberger, M
    Hurkmans, C
    Nestle, U
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    Affiliation
    Department of Radiation Oncology, University Medical Center Freiburg, Freiburg, Germany
    Issue Date
    2015-07
    
    Metadata
    Show full item record
    Abstract
    Evidence supports stereotactic body radiotherapy (SBRT) as a curative treatment option for inoperable early stage non-small-cell lung cancer (NSCLC) resulting in high rates of tumour control and low risk of toxicity. However, promising results are mainly derived from SBRT of peripheral pulmonary lesions, whereas SBRT for the central tumours can lead to severe radiation sequelae owing to the spatial proximity to the serial organs at risk. Robust data on the tolerance of mediastinal structures to high-dose hypofractionated radiation are limited; furthermore, there are many open questions regarding the efficiency, safety and response assessment of SBRT in inoperable, centrally located early stage NSCLC, which are addressed in a prospective multicentre study [sponsored by the European Organization for Research and Treatment of Cancer (EORTC 22113-08113-LungTech)]. In this review, we summarize the current status regarding SBRT for centrally located early stage NSCLC that leads to the rationale of the LungTech trial. Outline and some essential features of the study with focus on a summary of current experiences in dose/fraction-toxicity coherences after SBRT to the mediastinal structures that lead to LungTech normal tissue constraints are provided.
    Citation
    LungTech, an EORTC Phase II trial of stereotactic body radiotherapy for centrally located lung tumours: a clinical perspective. 2015, 88 (1051):20150036 Br J Radiol
    Journal
    The British Journal of Radiology
    URI
    http://hdl.handle.net/10541/578679
    DOI
    10.1259/bjr.20150036
    PubMed ID
    25873481
    Type
    Article
    Language
    en
    ISSN
    1748-880X
    ae974a485f413a2113503eed53cd6c53
    10.1259/bjr.20150036
    Scopus Count
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