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    Tumoural expression of connective tissue growth factor (CTGF) impacts on survival in patients diagnosed with hepatocellular carcinoma (HCC).

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    Authors
    Lamarca, Angela
    Mendiola, M
    Bernal, E
    Heredia, V
    Díaz, E
    Miguel, M
    Pastrian, L
    Burgos, E
    Feliu, J
    Barriuso, J
    Affiliation
    Translational Oncology Group, IdIPAZ, La Paz University Hospital, Faculty of Life Sciences, University of Manchester, Manchester, UK
    Issue Date
    2015
    
    Metadata
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    Abstract
    Hepatocellular carcinoma (HCC) tends to develop in the liver when there is a high level of background inflammation (cirrhosis). Treatment options are limited and mainly based on systemic therapies such as anti-angiogenic drugs (e.g. sorafenib). Connective tissue growth factor (CTGF) is a matricellular protein involved in inflammation, tumour growth and angiogenesis. The aim of this study is to determine the expression of CTGF and hypoxia inducible factors (HIF) in HCC and to clarify its impact on relapse and survival.
    Citation
    Tumoural expression of connective tissue growth factor (CTGF) impacts on survival in patients diagnosed with hepatocellular carcinoma (HCC). 2015, 15 (5):435-44 Curr Cancer Drug Targets
    Journal
    Current Cancer Drug Targets
    URI
    http://hdl.handle.net/10541/578678
    PubMed ID
    25847009
    Type
    Article
    Language
    en
    ISSN
    1873-5576
    Collections
    All Christie Publications

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