Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma.
Authors
Oguejiofor, Kenneth KHall, J
Slater, C
Betts, G
Hall, G
Slevin, Nicholas J
Dovedi, S
Stern, Peter L
West, Catharine M L
Affiliation
Translational Radiobiology Group, Institute of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, Wilmslow Road, ManchesterIssue Date
2015-09-15
Metadata
Show full item recordAbstract
Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than those with HPV-negative tumours. There is interest in de-escalating their treatment but strategies are needed for risk stratification to identify subsets with a poor prognosis. This study investigated tumour-infiltrating lymphocytes (TILs) in relation to HPV tumour status and patient survival.Citation
Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma. 2015, 113 (6):886-93 Br J CancerJournal
British Journal of CancerDOI
10.1038/bjc.2015.277PubMed ID
26313665Type
ArticleLanguage
enISSN
1532-1827ae974a485f413a2113503eed53cd6c53
10.1038/bjc.2015.277