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    Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma.

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    Authors
    Oguejiofor, Kenneth K
    Hall, J
    Slater, C
    Betts, G
    Hall, G
    Slevin, Nicholas J
    Dovedi, S
    Stern, Peter L
    West, Catharine M L
    Affiliation
    Translational Radiobiology Group, Institute of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, Wilmslow Road, Manchester
    Issue Date
    2015-09-15
    
    Metadata
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    Abstract
    Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than those with HPV-negative tumours. There is interest in de-escalating their treatment but strategies are needed for risk stratification to identify subsets with a poor prognosis. This study investigated tumour-infiltrating lymphocytes (TILs) in relation to HPV tumour status and patient survival.
    Citation
    Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma. 2015, 113 (6):886-93 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/577427
    DOI
    10.1038/bjc.2015.277
    PubMed ID
    26313665
    Type
    Article
    Language
    en
    ISSN
    1532-1827
    ae974a485f413a2113503eed53cd6c53
    10.1038/bjc.2015.277
    Scopus Count
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