Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma.
Authors
Oguejiofor, Kenneth KHall, J
Slater, C
Betts, G
Hall, G
Slevin, Nicholas J
Dovedi, S
Stern, Peter L
West, Catharine M L
Affiliation
Translational Radiobiology Group, Institute of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, Wilmslow Road, ManchesterIssue Date
2015-09-15
Metadata
Show full item recordAbstract
Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than those with HPV-negative tumours. There is interest in de-escalating their treatment but strategies are needed for risk stratification to identify subsets with a poor prognosis. This study investigated tumour-infiltrating lymphocytes (TILs) in relation to HPV tumour status and patient survival.Citation
Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma. 2015, 113 (6):886-93 Br J CancerJournal
British Journal of CancerDOI
10.1038/bjc.2015.277PubMed ID
26313665Type
ArticleLanguage
enISSN
1532-1827ae974a485f413a2113503eed53cd6c53
10.1038/bjc.2015.277
Scopus Count
Collections
Related articles
- CD8 infiltration is associated with disease control and tobacco exposure in intermediate-risk oropharyngeal cancer.
- Authors: Kemnade JO, Elhalawani H, Castro P, Yu J, Lai S, Ittmann M, Mohamed ASR, Lai SY, Fuller CD, Sikora AG, Sandulache VC
- Issue date: 2020 Jan 14
- Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma.
- Authors: Wongpattaraworakul W, Choi A, Buchakjian MR, Lanzel EA, Kd AR, Simons AL
- Issue date: 2024 Jun 26
- Comparison of Two Modern Survival Prediction Tools, SORG-MLA and METSSS, in Patients With Symptomatic Long-bone Metastases Who Underwent Local Treatment With Surgery Followed by Radiotherapy and With Radiotherapy Alone.
- Authors: Lee CC, Chen CW, Yen HK, Lin YP, Lai CY, Wang JL, Groot OQ, Janssen SJ, Schwab JH, Hsu FM, Lin WH
- Issue date: 2024 Dec 1
- Defining the optimum strategy for identifying adults and children with coeliac disease: systematic review and economic modelling.
- Authors: Elwenspoek MM, Thom H, Sheppard AL, Keeney E, O'Donnell R, Jackson J, Roadevin C, Dawson S, Lane D, Stubbs J, Everitt H, Watson JC, Hay AD, Gillett P, Robins G, Jones HE, Mallett S, Whiting PF
- Issue date: 2022 Oct
- Immune checkpoint expression on tumor-infiltrating lymphocytes (TIL) is dependent on HPV status in oropharyngeal carcinoma (OPSCC) - A single-cell RNA sequencing analysis.
- Authors: von Witzleben A, Grages A, Thomas J, Ezić J, Brunner C, Schuler PJ, Kraus JM, Kestler HA, Vahl JM, Doescher J, King EV, Ottensmeier CH, Hoffmann TK, Laban S
- Issue date: 2024 Dec