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    A presurgical window-of-opportunity study of metformin in obesity-driven endometrial cancer.

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    Authors
    Sivalingam, Vanitha
    McVey, R
    Gilmour, K
    Ali, S
    Roberts, C
    Renehan, Andrew G
    Kitchener, Henry C
    Crosbie, Emma J
    Affiliation
    Institute of Cancer Sciences, University of Manchester, Manchester, UK
    Issue Date
    2015-02-26
    
    Metadata
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    Abstract
    Metformin use is associated with reduced cancer risk in several observational studies of patients with type 2 diabetes. Results from preclinical studies in endometrial cancer show that metformin reduces cellular proliferation by inhibition of the PI3K-AKT-mTOR pathway. We tested the hypothesis that metformin would reduce cellular proliferation in vivo in atypical endometrial hyperplasia and endometrial endometrioid adenocarcinoma.
    Citation
    A presurgical window-of-opportunity study of metformin in obesity-driven endometrial cancer. 2015, 385 Suppl 1:S90 Lancet
    Journal
    Lancet
    URI
    http://hdl.handle.net/10541/577426
    DOI
    10.1016/S0140-6736(15)60405-6
    PubMed ID
    26312913
    Type
    Article
    Language
    en
    ISSN
    1474-547X
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0140-6736(15)60405-6
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