A presurgical window-of-opportunity study of metformin in obesity-driven endometrial cancer.
Renehan, Andrew G
Kitchener, Henry C
Crosbie, Emma J
AffiliationInstitute of Cancer Sciences, University of Manchester, Manchester, UK
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AbstractMetformin use is associated with reduced cancer risk in several observational studies of patients with type 2 diabetes. Results from preclinical studies in endometrial cancer show that metformin reduces cellular proliferation by inhibition of the PI3K-AKT-mTOR pathway. We tested the hypothesis that metformin would reduce cellular proliferation in vivo in atypical endometrial hyperplasia and endometrial endometrioid adenocarcinoma.
CitationA presurgical window-of-opportunity study of metformin in obesity-driven endometrial cancer. 2015, 385 Suppl 1:S90 Lancet
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