• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Jayson, Gordon C
    Hansen, S
    Miller, G
    Cole, Claire L
    Rushton, Graham
    Avizienyte, Egle
    Gardiner, J
    Affiliation
    Christie Hospital, Institute of Cancer Studies, University of Manchester, Manchester, M20 4BX, UK
    Issue Date
    2015-09-18
    
    Metadata
    Show full item record
    Abstract
    The multigram-scale synthesis of a sulfation-site programmed heparin-like dodecasaccharide is described. Evaluation alongside dodecasaccharides lacking this single glucosamine O6-sulfation, or having per-O6-sulfation, shows that site-specific modification of the terminal glucosamine dramatically interconverts regulation of in vitro and in vivo biology mediated by the two important chemokines, CXCL12 (SDF1α) or CXCL8 (IL-8).
    Citation
    Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology. 2015, 51 (72):13846-9 Chem Commun
    Journal
    Chemical Communications
    URI
    http://hdl.handle.net/10541/577424
    DOI
    10.1039/c5cc05222j
    PubMed ID
    26234943
    Type
    Article
    Language
    en
    ISSN
    1364-548X
    ae974a485f413a2113503eed53cd6c53
    10.1039/c5cc05222j
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis.
    • Authors: Cole CL, Hansen SU, Baráth M, Rushton G, Gardiner JM, Avizienyte E, Jayson GC
    • Issue date: 2010 Jul 21
    • Regulation of FGF-1 mitogenic activity by heparan sulfate oligosaccharides is dependent on specific structural features: differential requirements for the modulation of FGF-1 and FGF-2.
    • Authors: Pye DA, Vivès RR, Hyde P, Gallagher JT
    • Issue date: 2000 Nov
    • Synthetic heparin and heparan sulfate oligosaccharides and their protein interactions.
    • Authors: Zulueta MM, Lin SY, Hu YP, Hung SC
    • Issue date: 2013 Dec
    • Synthetic Site-Selectively Mono-6-O-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties In Vitro and Sensitizes Tumors to Cisplatin In Vivo.
    • Authors: Avizienyte E, Cole CL, Rushton G, Miller GJ, Bugatti A, Presta M, Gardiner JM, Jayson GC
    • Issue date: 2016
    • Modulatory effects of heparin and short-length oligosaccharides of heparin on the metastasis and growth of LMD MDA-MB 231 breast cancer cells in vivo.
    • Authors: Mellor P, Harvey JR, Murphy KJ, Pye D, O'Boyle G, Lennard TW, Kirby JA, Ali S
    • Issue date: 2007 Sep 17
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.