AffiliationDepartment of Endocrinology, The Christie Hospital NHS Foundation Trust, Manchester, UK
MetadataShow full item record
AbstractSurvivors who have received pelvic radiotherapy make up many of the long-term cancer population, with therapies for gynaecological, bowel, bladder and prostate malignancies. Individuals who receive radiotherapy to the pelvis as part of their cancer treatment are at risk of insufficiency fractures. Symptoms of insufficiency fractures include pelvic and back pain and immobility, which can affect substantially quality of life. This constellation of symptoms can occur within 2 months of radiotherapy up to 63 months post-treatment, with a median incidence of 6-20 months. As a condition it is under reported and evidence is poor as to the contributing risk factors, causation and best management to improve the patient's bone health and mobility. As radiotherapy advances, chronic symptoms, such as insufficiency fractures, as a consequence of treatment need to be better understood and reviewed. This overview explores the current evidence for the effect of radiotherapy on bone health and insufficiency fractures and identifies what we know and where gaps in our knowledge lie. The overview concludes with the need to take seriously complaints of pelvic pain from patients after pelvic radiotherapy and to investigate and manage these symptoms more effectively. There is a clear need for definitive research in this field to provide the evidence-based guidance much needed in practice.
CitationBone health and pelvic radiotherapy. 2015: Clin Oncol
- Insufficiency fractures in patients treated with pelvic radiotherapy and chemotherapy for uterine and cervical cancer.
- Authors: Mehmood Q, Beardwood M, Swindell R, Greenhalgh S, Wareham T, Barraclough L, Livsey J, Davidson SE
- Issue date: 2014 Jan
- Insufficiency fractures after pelvic radiotherapy in patients with prostate cancer.
- Authors: Iğdem S, Alço G, Ercan T, Barlan M, Ganiyusufoğlu K, Unalan B, Turkan S, Okkan S
- Issue date: 2010 Jul 1
- Pelvic fractures after radiotherapy for cervical cancer: implications for survivors.
- Authors: Schmeler KM, Jhingran A, Iyer RB, Sun CC, Eifel PJ, Soliman PT, Ramirez PT, Frumovitz M, Bodurka DC, Sood AK
- Issue date: 2010 Feb 1
- Risk of pelvic fractures in older women following pelvic irradiation.
- Authors: Baxter NN, Habermann EB, Tepper JE, Durham SB, Virnig BA
- Issue date: 2005 Nov 23
- From radiation osteitis to osteoradionecrosis: incidence and MR morphology of radiation-induced sacral pathologies following pelvic radiotherapy.
- Authors: Meixel AJ, Hauswald H, Delorme S, Jobke B
- Issue date: 2018 Aug