Balloon cell urethral melanoma: differential diagnosis and management.
Authors
McComiskey, MarkIavazzo, Christos
Datta, Meghna
Slade, Richard J
Winter-Roach, Brett
Lambe, Gerard F
Sangar, Vijay K
Smith, Michael
Affiliation
Gynaecological Oncology Department, Christie Hospital, Manchester M20 4BX, UKIssue Date
2015
Metadata
Show full item recordAbstract
Introduction. Primary malignant melanoma of the urethra is a rare tumour (0.2% of all melanomas) that most commonly affects the meatus and distal urethra and is three times more common in women than men. Case. A 76-year-old lady presented with vaginal pain and discharge. On examination, a 4 cm mass was noted in the vagina and biopsy confirmed melanoma of a balloon type. Preoperative CT showed no distant metastases and an MRI scan of the pelvis demonstrated no associated lymphadenopathy. She underwent anterior exenterative surgery and vaginectomy also. Histology confirmed a urethral nodular malignant melanoma. Discussion. First-line treatment of melanoma is often surgical. Adjuvant treatment including chemotherapy, radiotherapy, or immunotherapy has also been reported. Even with aggressive management, malignant melanoma of the urogenital tract generally has a poor prognosis. Recurrence rates are high and the mean period between diagnosis and recurrence is 12.5 months. A 5-year survival rate of less than 20% has been reported in balloon cell melanomas along with nearly 20% developing local recurrence. Conclusion. To the best of our knowledge, this case is the first report of balloon cell melanoma arising in the urethra. The presentation and surgical management has been described and a literature review provided.Citation
Balloon cell urethral melanoma: differential diagnosis and management. 2015, 2015:919584 Case Rep Obstet GynecolJournal
Case Reports in Obstetrics and GynecologyDOI
10.1155/2015/919584PubMed ID
26257971Type
ArticleLanguage
enISSN
2090-6684ae974a485f413a2113503eed53cd6c53
10.1155/2015/919584