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    Effect of food on the pharmacokinetics of Olaparib after oral dosing of the capsule formulation in patients with advanced solid tumors.

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    Authors
    Rolfo, C
    Swaisland, H
    Leunen, K
    Rutten, A
    Soetekouw, P
    Slater, S
    Verheul, H
    Fielding, A
    So, K
    Bannister, W
    Dean, Emma J
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    Affiliation
    Univ Antwerp Hosp, Dept Oncol, Early Clin Trials Unit, B-2650 Edegem, Belgium
    Issue Date
    2015-06
    
    Metadata
    Show full item record
    Abstract
    The oral, potent poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib, is well tolerated at doses of ≤400 mg twice daily (BID) (administered as capsules), and has shown efficacy in patients with advanced BRCA-mutated ovarian and breast cancer.
    Citation
    Effect of Food on the Pharmacokinetics of Olaparib after Oral Dosing of the Capsule Formulation in Patients with Advanced Solid Tumors. 2015, 32 (6):510-22 Adv Ther
    Journal
    Advances in Therapy
    URI
    http://hdl.handle.net/10541/566201
    DOI
    10.1007/s12325-015-0214-4
    PubMed ID
    26048134
    Type
    Article
    Language
    en
    ISSN
    1865-8652
    ae974a485f413a2113503eed53cd6c53
    10.1007/s12325-015-0214-4
    Scopus Count
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