MiRNA-based therapeutic intervention of cancer.
| dc.contributor.author | Naidu, Srivatsava | |
| dc.contributor.author | Magee, Peter | |
| dc.contributor.author | Garofalo, Michela | |
| dc.date.accessioned | 2015-08-05T09:01:40Z | en |
| dc.date.available | 2015-08-05T09:01:40Z | en |
| dc.date.issued | 2015 | en |
| dc.identifier.citation | MiRNA-based therapeutic intervention of cancer. 2015, 8:68 J Hematol Oncol | en |
| dc.identifier.issn | 1756-8722 | en |
| dc.identifier.pmid | 26062952 | en |
| dc.identifier.doi | 10.1186/s13045-015-0162-0 | en |
| dc.identifier.uri | http://hdl.handle.net/10541/565090 | en |
| dc.description.abstract | MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus helping to determine cell fate. MiRNAs have emerged as crucial molecules in cancer research, in which recent studies have linked erratic expression of miRNAs to carcinogenesis and have provided solid evidence for their potential in cancer therapy. This review briefly summarises the recent knowledge on the involvement of miRNAs in tumourigenesis and reviews current studies on the therapeutic strategies and advances in the delivery of miRNAs. | |
| dc.language.iso | en | en |
| dc.rights | Archived with thanks to Journal of hematology & oncology | en |
| dc.title | MiRNA-based therapeutic intervention of cancer. | en |
| dc.type | Article | en |
| dc.contributor.department | Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK | en |
| dc.identifier.journal | Journal of Hematology & Oncology | en |
| html.description.abstract | MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus helping to determine cell fate. MiRNAs have emerged as crucial molecules in cancer research, in which recent studies have linked erratic expression of miRNAs to carcinogenesis and have provided solid evidence for their potential in cancer therapy. This review briefly summarises the recent knowledge on the involvement of miRNAs in tumourigenesis and reviews current studies on the therapeutic strategies and advances in the delivery of miRNAs. |