Affiliation
Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UKIssue Date
2015
Metadata
Show full item recordAbstract
MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus helping to determine cell fate. MiRNAs have emerged as crucial molecules in cancer research, in which recent studies have linked erratic expression of miRNAs to carcinogenesis and have provided solid evidence for their potential in cancer therapy. This review briefly summarises the recent knowledge on the involvement of miRNAs in tumourigenesis and reviews current studies on the therapeutic strategies and advances in the delivery of miRNAs.Citation
MiRNA-based therapeutic intervention of cancer. 2015, 8:68 J Hematol OncolJournal
Journal of Hematology & OncologyDOI
10.1186/s13045-015-0162-0PubMed ID
26062952Type
ArticleLanguage
enISSN
1756-8722ae974a485f413a2113503eed53cd6c53
10.1186/s13045-015-0162-0