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dc.contributor.authorMiller, B
dc.contributor.authorMorton, J
dc.contributor.authorPinese, M
dc.contributor.authorSaturno, Grazia
dc.contributor.authorJamieson, N
dc.contributor.authorMcGhee, E
dc.contributor.authorTimpson, Paul
dc.contributor.authorLeach, J
dc.contributor.authorMcGarry, L
dc.contributor.authorShanks, E
dc.contributor.authorBailey, P
dc.contributor.authorChang, D
dc.contributor.authorOien, K
dc.contributor.authorKarim, S
dc.contributor.authorAu, A
dc.contributor.authorSteele, C
dc.contributor.authorCarter, C
dc.contributor.authorMcKay, C
dc.contributor.authorAnderson, K
dc.contributor.authorEvans, T
dc.contributor.authorMarais, Richard
dc.contributor.authorSpringer, C
dc.contributor.authorBiankin, A
dc.contributor.authorErler, J
dc.contributor.authorSansom, O
dc.date.accessioned2015-07-30T08:57:20Zen
dc.date.available2015-07-30T08:57:20Zen
dc.date.issued2015-06-15en
dc.identifier.citationTargeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. 2015: EMBO Mol Meden
dc.identifier.issn1757-4684en
dc.identifier.pmid26077591en
dc.identifier.doi10.15252/emmm.201404827en
dc.identifier.urihttp://hdl.handle.net/10541/561254en
dc.description.abstractPancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related mortality. Despite significant advances made in the treatment of other cancers, current chemotherapies offer little survival benefit in this disease. Pancreaticoduodenectomy offers patients the possibility of a cure, but most will die of recurrent or metastatic disease. Hence, preventing metastatic disease in these patients would be of significant benefit. Using principal component analysis (PCA), we identified a LOX/hypoxia signature associated with poor patient survival in resectable patients. We found that LOX expression is upregulated in metastatic tumors from Pdx1-Cre Kras(G12D/+) Trp53(R172H/+) (KPC) mice and that inhibition of LOX in these mice suppressed metastasis. Mechanistically, LOX inhibition suppressed both migration and invasion of KPC cells. LOX inhibition also synergized with gemcitabine to kill tumors and significantly prolonged tumor-free survival in KPC mice with early-stage tumors. This was associated with stromal alterations, including increased vasculature and decreased fibrillar collagen, and increased infiltration of macrophages and neutrophils into tumors. Therefore, LOX inhibition is able to reverse many of the features that make PDAC inherently refractory to conventional therapies and targeting LOX could improve outcome in surgically resectable disease.
dc.languageENGen
dc.language.isoenen
dc.rightsArchived with thanks to EMBO molecular medicineen
dc.titleTargeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK Beatson Institute Garscube Estate, Glasgow, UKen
dc.identifier.journalEMBO Molecular Medicineen
html.description.abstractPancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related mortality. Despite significant advances made in the treatment of other cancers, current chemotherapies offer little survival benefit in this disease. Pancreaticoduodenectomy offers patients the possibility of a cure, but most will die of recurrent or metastatic disease. Hence, preventing metastatic disease in these patients would be of significant benefit. Using principal component analysis (PCA), we identified a LOX/hypoxia signature associated with poor patient survival in resectable patients. We found that LOX expression is upregulated in metastatic tumors from Pdx1-Cre Kras(G12D/+) Trp53(R172H/+) (KPC) mice and that inhibition of LOX in these mice suppressed metastasis. Mechanistically, LOX inhibition suppressed both migration and invasion of KPC cells. LOX inhibition also synergized with gemcitabine to kill tumors and significantly prolonged tumor-free survival in KPC mice with early-stage tumors. This was associated with stromal alterations, including increased vasculature and decreased fibrillar collagen, and increased infiltration of macrophages and neutrophils into tumors. Therefore, LOX inhibition is able to reverse many of the features that make PDAC inherently refractory to conventional therapies and targeting LOX could improve outcome in surgically resectable disease.


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