KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease.
Affiliation
Oryzon Genomics S.A., Carrer Sant Ferran 74, 08940 Cornella de Llobregat, Barcelona,Issue Date
2015-06
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Histone methylation and demethylation are important processes associated with the regulation of gene transcription, and alterations in histone methylation status have been linked to a large number of human diseases. Initially thought to be an irreversible process, histone methylation is now known to be reversed by two families of proteins containing over 30 members that act to remove methyl groups from specific lysine residues present in the tails of histone H3 and histone H4. A rapidly growing number of reports have implicated the FAD-dependent lysine specific demethylase (KDM1) family in cancer, and several small-molecule inhibitors are in development for the treatment of cancer. An additional role has emerged for KDM1 in brain function, offering additional opportunities for the development of novel therapeutic strategies in neurodegenerative disease. A decade after the identification of KDM1A as a histone demethylase, the first selective inhibitors have now reached the clinic.Citation
KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease. 2015, 7 (4):609-26 EpigenomicsJournal
EpigenomicsDOI
10.2217/epi.15.9PubMed ID
26111032Type
ArticleLanguage
enISSN
1750-192Xae974a485f413a2113503eed53cd6c53
10.2217/epi.15.9
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