• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Joshi, P
    Jeon, Y
    Laganà, A
    Middleton, J
    Secchiero, P
    Garofalo, Michela
    Croce, C
    Affiliation
    Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH
    Issue Date
    2015-07-14
    
    Metadata
    Show full item record
    Abstract
    Nonsmall cell lung cancer (NSCLC) is one of the leading causes of death worldwide. TNF-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis in malignant cells without inducing significant toxicity in normal cells. However, several carcinomas, including lung cancer, remain resistant to TRAIL. MicroRNAs (miRNAs) are small noncoding RNAs of ∼24 nt that block mRNA translation and/or negatively regulate its stability. They are often aberrantly expressed in cancer and have been implicated in increasing susceptibility or resistance to TRAIL-induced apoptosis by inhibiting key functional proteins. Here we show that miR-148a is down-regulated in cells with acquired TRAIL-resistance compared with TRAIL-sensitive cells. Enforced expression of miR-148a sensitized cells to TRAIL and reduced lung tumorigenesis in vitro and in vivo through the down-modulation of matrix metalloproteinase 15 (MMP15) and Rho-associated kinase 1 (ROCK1). These findings suggest that miR-148a acts as a tumor suppressor and might have therapeutic application in the treatment of NSCLC.
    Citation
    MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC. 2015, 112 (28):8650-5 Proc Natl Acad Sci USA
    Journal
    Proceedings of the National Academy of Sciences of the United States of America
    URI
    http://hdl.handle.net/10541/560922
    DOI
    10.1073/pnas.1500886112
    PubMed ID
    26124099
    Type
    Article
    Language
    en
    ISSN
    1091-6490
    ae974a485f413a2113503eed53cd6c53
    10.1073/pnas.1500886112
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • MiR-760 enhances TRAIL sensitivity in non-small cell lung cancer via targeting the protein FOXA1.
    • Authors: Zhang X, Wang L, Liu Y, Huang W, Cheng D
    • Issue date: 2018 Mar
    • Hypermethylation of the death-associated protein kinase promoter attenuates the sensitivity to TRAIL-induced apoptosis in human non-small cell lung cancer cells.
    • Authors: Tang X, Wu W, Sun SY, Wistuba II, Hong WK, Mao L
    • Issue date: 2004 Dec
    • MicroRNA-148a Suppresses Invasion and Metastasis of Human Non-Small-Cell Lung Cancer.
    • Authors: Li J, Yu T, Cao J, Liu L, Liu Y, Kong HW, Zhu MX, Lin HC, Chu DD, Yao M, Yan MX
    • Issue date: 2015
    • MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer.
    • Authors: Garofalo M, Quintavalle C, Di Leva G, Zanca C, Romano G, Taccioli C, Liu CG, Croce CM, Condorelli G
    • Issue date: 2008 Jun 19
    • MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non-small-cell lung cancer through BIM down-regulation.
    • Authors: Romano G, Acunzo M, Garofalo M, Di Leva G, Cascione L, Zanca C, Bolon B, Condorelli G, Croce CM
    • Issue date: 2012 Oct 9
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.