The combination of cyclophosphamide and human T cells genetically engineered to target CD19 can eradicate established B-cell lymphoma.
Affiliation
Cancer Research UK Department of Medical Oncology, University of Manchester, Manchester, UK.Issue Date
2008-07
Metadata
Show full item recordAbstract
T cells genetically engineered to express tumour-targeting receptors are attractive anti-cancer therapeutic agents. Human T cells engrafted with a chimeric receptor specific for the B-cell lymphoma antigen CD19 fused to the CD3zeta receptor (aCD19z) are functional in vitro. Current successful clinical protocols targeting melanoma use pre-conditioning chemotherapy in combination with T cells. This study demonstrated that interleukin-2 expanded aCD19z T cells combined with cyclophosphamide effectively treated five-day established Raji B-cell lymphoma in an immunocompromised model system with 50% of mice surviving >100 days. This observation strongly supports the combination of antibody targeted T cells with chemotherapy as a novel approach for the therapy of CD19(+) B-cell malignancies.Citation
The combination of cyclophosphamide and human T cells genetically engineered to target CD19 can eradicate established B-Cell lymphoma. 2008, 142 (1):65-8 Br. J. Haematol.Journal
British Journal of HaematologyDOI
10.1111/j.1365-2141.2008.07145.xPubMed ID
18477047Type
ArticleLanguage
enISSN
1365-2141ae974a485f413a2113503eed53cd6c53
10.1111/j.1365-2141.2008.07145.x
Scopus Count
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