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dc.contributor.authorKershaw, Stephen
dc.contributor.authorCummings, Jeffrey
dc.contributor.authorMorris, Karen
dc.contributor.authorTugwood, Jonathan D
dc.contributor.authorDive, Caroline
dc.date.accessioned2015-07-09T09:19:02Zen
dc.date.available2015-07-09T09:19:02Zen
dc.date.issued2015en
dc.identifier.citationOptimisation of immunofluorescence methods to determine MCT1 and MCT4 expression in circulating tumour cells. 2015, 15:387 BMC Canceren
dc.identifier.issn1471-2407en
dc.identifier.pmid25957999en
dc.identifier.doi10.1186/s12885-015-1382-yen
dc.identifier.urihttp://hdl.handle.net/10541/559323en
dc.description.abstractThe monocarboxylate transporter-1 (MCT1) represents a novel target in rational anticancer drug design while AZD3965 was developed as an inhibitor of this transporter and is undergoing Phase I clinical trials ( http://www.clinicaltrials.gov/show/NCT01791595 ). We describe the optimisation of an immunofluorescence (IF) method for determination of MCT1 and MCT4 in circulating tumour cells (CTC) as potential prognostic and predictive biomarkers of AZD3965 in cancer patients.
dc.language.isoenen
dc.rightsArchived with thanks to BMC canceren
dc.titleOptimisation of immunofluorescence methods to determine MCT1 and MCT4 expression in circulating tumour cells.en
dc.typeArticleen
dc.contributor.departmentClinical and Experimental Pharmacology Group, Manchester Cancer Research Centre, Cancer Research UK Manchester Institute, University of Manchesteren
dc.identifier.journalBMC Canceren
html.description.abstractThe monocarboxylate transporter-1 (MCT1) represents a novel target in rational anticancer drug design while AZD3965 was developed as an inhibitor of this transporter and is undergoing Phase I clinical trials ( http://www.clinicaltrials.gov/show/NCT01791595 ). We describe the optimisation of an immunofluorescence (IF) method for determination of MCT1 and MCT4 in circulating tumour cells (CTC) as potential prognostic and predictive biomarkers of AZD3965 in cancer patients.


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