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    Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.

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    Authors
    Regha, K
    Assi, S
    Tsoulaki, Olga
    Gilmour, J
    Lacaud, Georges
    Bonifer, C
    Affiliation
    School of Cancer Sciences, Institute for Biomedical Research, University of Birmingham
    Issue Date
    2015
    
    Metadata
    Show full item record
    Abstract
    Acute myeloid leukaemia (AML) is characterized by a block in myeloid differentiation the stage of which is dependent on the nature of the transforming oncogene and the developmental stage of the oncogenic hit. This is also true for the t(8;21) translocation that gives rise to the RUNX1-ETO fusion protein and initiates the most common form of human AML. Here we study the differentiation of mouse embryonic stem cells expressing an inducible RUNX1-ETO gene into blood cells as a model, combined with genome-wide analyses of transcription factor binding and gene expression. RUNX1-ETO interferes with both the activating and repressive function of its normal counterpart, RUNX1, at early and late stages of blood cell development. However, the response of the transcriptional network to RUNX1-ETO expression is developmental stage specific, highlighting the molecular mechanisms determining specific target cell expansion after an oncogenic hit.
    Citation
    Developmental-stage-dependent transcriptional response to leukaemic oncogene expression. 2015, 6:7203 Nat Commun
    Journal
    Nature Communications
    URI
    http://hdl.handle.net/10541/559319
    DOI
    10.1038/ncomms8203
    PubMed ID
    26018585
    Type
    Article
    Language
    en
    ISSN
    2041-1723
    ae974a485f413a2113503eed53cd6c53
    10.1038/ncomms8203
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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