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    Phosphohistone-H3 (PHH3) is prognostic relevant in Merkel cell carcinomas but Merkel cell polyomavirus is a more powerful prognostic factor than AJCC clinical stage, PHH3, Ki-67 or mitotic indices.

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    Authors
    Iwasaki, T
    Matsushita, M
    Nonaka, Daisuke
    Kato, M
    Nagata, K
    Murakami, I
    Hayashi, K
    Affiliation
    Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine, Yonago, Japan
    Issue Date
    2015-05-18
    
    Metadata
    Show full item record
    Abstract
    Merkel cell carcinomas (MCCs) associated with Merkel cell polyomavirus (MCPyV) have better prognosis than those without MCPyV. The relationship between mitotic index (MI) and MCC outcome has remained elusive because of the difficulty in differentiating mitotic cells from apoptotic ones. We evaluated the role of phosphohistone-H3 (PHH3) (Ser10), a new mitotic count biomarker, in MCPyV-positive or -negative MCC patients, and assessed its prognostic value in comparison to Ki-67 labeling index or MI using hematoxylin and eosin (HE) staining. We compared the prognostic value of PHH3 mitotic index with that of MI by HE in 19 MCPyV-positive and 9 MCPyV-negative MCC patients. PHH3-positive immunoreactivity was mostly observed in mitotic figures. Multivariate analysis significantly showed that MCPyV status (HR, 0.004; 95% CI 0.0003-0.058) and the American Joint Committee of Cancer (AJCC) stage (HR, 5.02; 95% CI 1.23-20.51) were observed as significantly independent prognostic factors for OS. PHH3-positive cell counts/10 HPF was a slightly significant independent prognostic factor for OS (HR, 4.96; 95% CI 0.93-26.55). PHH3-positive MI and MCPyV status in MCC patients are useful in prognostication, although MCPyV-infection is a more powerful prognostic factor in MCCs than the AJCC scheme on proliferation or mitotic indices.
    Citation
    Phosphohistone-H3 (PHH3) is prognostic relevant in Merkel cell carcinomas but Merkel cell polyomavirus is a more powerful prognostic factor than AJCC clinical stage, PHH3, Ki-67 or mitotic indices. 2015: Pathol Int
    Journal
    Pathology International
    URI
    http://hdl.handle.net/10541/558737
    DOI
    10.1111/pin.12305
    PubMed ID
    25982855
    Type
    Article
    Language
    en
    ISSN
    1440-1827
    ae974a485f413a2113503eed53cd6c53
    10.1111/pin.12305
    Scopus Count
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    All Christie Publications

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