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    FISHing Tips: What Every Clinician Should Know About 1p19q Analysis in Gliomas Using Fluorescence in situ Hybridisation.

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    Authors
    Pinkham, Mark B
    Telford, Nicholas
    Whitfield, Gillian A
    Colaco, Rovel J
    O'Neill, Fran
    McBain, Catherine A
    Affiliation
    Clinical Oncology, Christie NHS Foundation Trust, Manchester, UK
    Issue Date
    2015-05-10
    
    Metadata
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    Abstract
    1p19q co-deletion is a chromosomal alteration associated with primary brain tumours of oligodendroglial histology. It is an established predictive and prognostic biomarker that informs whether patients are offered radiotherapy, chemotherapy or both. In the near future, 1p19q co-deletion status may also be incorporated into the reclassification of gliomas. Analysis is commonly carried out using fluorescence in situ hybridisation (FISH) because it is a reliable and validated laboratory technique. The result is generally considered to be dichotomous (1p19q co-deletion present or absent), but there are subtleties in interpretation that are of clinical relevance. Separate centres may interpret certain chromosome deletion patterns differently. Pivotal trials in mixed and pure anaplastic oligodendrogliomas have used slightly different FISH probe ratios as the cut-off for chromosome deletion. Here we review the clinical implications of this variability and review the process of 1p19q co-deletion assessment using FISH in gliomas from a clinician's perspective. We also consider common alternative methods of analysis.
    Citation
    FISHing Tips: What Every Clinician Should Know About 1p19q Analysis in Gliomas Using Fluorescence in situ Hybridisation. 2015: Clin Oncol
    Journal
    Clinical Oncology
    URI
    http://hdl.handle.net/10541/558727
    DOI
    10.1016/j.clon.2015.04.008
    PubMed ID
    25971646
    Type
    Article
    Language
    en
    ISSN
    1433-2981
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clon.2015.04.008
    Scopus Count
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