Authors
Elkord, EyadAffiliation
Immunology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK. eelkord@picr.man.ac.ukIssue Date
2008
Metadata
Show full item recordAbstract
Natural CD4+CD25+FoxP3+ regulatory T cells (Treg) actively suppress physiological and pathological responses, therefore playing a critical role in controlling peripheral tolerance to self antigens and maintaining immune homeostasis. In normal individuals, natural Treg and interleukin- 10-secreting Treg are able to suppress Th2 responses to allergens, whereas lower levels of Treg or defect in their functionality have been described as potential mechanisms for inducing allergic diseases. In animal models, adoptive transfer of CD4+CD25+Treg has been shown as a promising strategy for preventing or treating allergic disorders. Recent studies show that induction of Treg activity is associated with suppression of allergic responses in allergic patients treated with specific immunotherapy. Herein, I review the potential of Treg as exciting targets for developing new immunotherapeutic strategies for treating allergic diseases.Citation
Novel therapeutic strategies by regulatory T cells in allergy. 2008, 94:150-7 Chem Immunol AllergyJournal
Chemical Immunology and AllergyDOI
10.1159/000154999PubMed ID
18802345Type
ArticleLanguage
enISSN
1660-2242ae974a485f413a2113503eed53cd6c53
10.1159/000154999
Scopus Count
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