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    Novel therapeutic strategies by regulatory T cells in allergy.

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    Authors
    Elkord, Eyad
    Affiliation
    Immunology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK. eelkord@picr.man.ac.uk
    Issue Date
    2008
    
    Metadata
    Show full item record
    Abstract
    Natural CD4+CD25+FoxP3+ regulatory T cells (Treg) actively suppress physiological and pathological responses, therefore playing a critical role in controlling peripheral tolerance to self antigens and maintaining immune homeostasis. In normal individuals, natural Treg and interleukin- 10-secreting Treg are able to suppress Th2 responses to allergens, whereas lower levels of Treg or defect in their functionality have been described as potential mechanisms for inducing allergic diseases. In animal models, adoptive transfer of CD4+CD25+Treg has been shown as a promising strategy for preventing or treating allergic disorders. Recent studies show that induction of Treg activity is associated with suppression of allergic responses in allergic patients treated with specific immunotherapy. Herein, I review the potential of Treg as exciting targets for developing new immunotherapeutic strategies for treating allergic diseases.
    Citation
    Novel therapeutic strategies by regulatory T cells in allergy. 2008, 94:150-7 Chem Immunol Allergy
    Journal
    Chemical Immunology and Allergy
    URI
    http://hdl.handle.net/10541/55825
    DOI
    10.1159/000154999
    PubMed ID
    18802345
    Type
    Article
    Language
    en
    ISSN
    1660-2242
    ae974a485f413a2113503eed53cd6c53
    10.1159/000154999
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research
    Immunology

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