Affiliation
Academic Radiation Oncology, The University of Manchester, Christie Hospital, Manchester M20 4BX, UK. catharine.west@manchester.ac.ukIssue Date
2008-10
Metadata
Show full item recordAbstract
High epidermal growth factor receptor (EGFR) expression is a feature of human tumours and is an adverse prognostic factor for radiotherapy outcome. High expression is associated with benefit from accelerated radiotherapy in patients with head and neck squamous cell carcinoma. Anti-EGFR strategies potentiate the effects of radiotherapy and the inhibition of deoxyribonucleic acid repair appears to be important amongst a wide range of mechanisms, which include effects on angiogenesis, differentiation and the immunological response. There is considerable interest in exploring combined modality therapies involving radiation and EGFR antagonists for the curative treatment of cancer patients. Important issues in designing new trials are to investigate optimal scheduling and to establish biobanks to develop biomarkers for future patient selection.Citation
Epidermal growth factor receptor-targeted therapy. 2008, 81 Spec No 1:S36-44 Br J RadiolJournal
The British Journal of RadiologyDOI
10.1259/bjr/32798755PubMed ID
18819997Type
ArticleLanguage
enISSN
1748-880Xae974a485f413a2113503eed53cd6c53
10.1259/bjr/32798755