Primary diffuse large B-cell lymphoma of the breast: prognostic factors and outcomes of a study by the International Extranodal Lymphoma Study Group.
Authors
Ryan, GMartinelli, Giovanni
Kuper-Hommel, M
Tsang, R
Pruneri, G
Yuen, K
Roos, D
Lennard, A
Devizzi, L
Crabb, S
Hossfeld, D
Pratt, Guy
Dell'Olio, M
Choo, S P
Bociek, R G
Radford, John A
Lade, S
Gianni, A M
Zucca, E
Cavalli, Franco
Seymour, J F
Affiliation
Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Australia. gail.ryan@petermac.orgIssue Date
2008-02
Metadata
Show full item recordAbstract
BACKGROUND: Primary diffuse large B-cell lymphoma (DLBCL) of breast is rare. We aimed to define clinical features, prognostic factors, patterns of failure, and treatment outcomes. PATIENTS AND METHODS: A retrospective international study of 204 eligible patients presenting to the International Extranodal Lymphoma Study Group-affiliated institutions from 1980 to 2003. RESULTS: Median age was 64 years, with 95% of patients presenting with unilateral disease. Median overall survival (OS) was 8.0 years, and median progression-free survival 5.5 years. In multifactor analysis, favourable International Prognostic Index score, anthracycline-containing chemotherapy, and radiotherapy (RT) were significantly associated with longer OS (each P < or = 0.03). There was no benefit from mastectomy, as opposed to biopsy or lumpectomy only. At a median follow-up time of 5.5 years, 37% of patients had progressed--16% in the same or contralateral breast, 5% in the central nervous system, and 14% in other extranodal sites. CONCLUSIONS: The combination of limited surgery, anthracycline-containing chemotherapy, and involved-field RT produced the best outcome in the pre-rituximab era. A prospective trial on the basis of these results should be pursued to confirm these observations and to determine whether the impact of rituximab on the patterns of relapse and outcome parallels that of DLBCL presenting at other sites.Citation
Primary diffuse large B-cell lymphoma of the breast: prognostic factors and outcomes of a study by the International Extranodal Lymphoma Study Group. 2008, 19 (2):233-41 Ann. Oncol.Journal
Annals of OncologyDOI
10.1093/annonc/mdm471PubMed ID
17932394Type
ArticleLanguage
enISSN
1569-8041ae974a485f413a2113503eed53cd6c53
10.1093/annonc/mdm471
Scopus Count
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