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    Primary diffuse large B-cell lymphoma of the breast: prognostic factors and outcomes of a study by the International Extranodal Lymphoma Study Group.

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    Authors
    Ryan, G
    Martinelli, Giovanni
    Kuper-Hommel, M
    Tsang, R
    Pruneri, G
    Yuen, K
    Roos, D
    Lennard, A
    Devizzi, L
    Crabb, S
    Hossfeld, D
    Pratt, Guy
    Dell'Olio, M
    Choo, S P
    Bociek, R G
    Radford, John A
    Lade, S
    Gianni, A M
    Zucca, E
    Cavalli, Franco
    Seymour, J F
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    Affiliation
    Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Australia. gail.ryan@petermac.org
    Issue Date
    2008-02
    
    Metadata
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    Abstract
    BACKGROUND: Primary diffuse large B-cell lymphoma (DLBCL) of breast is rare. We aimed to define clinical features, prognostic factors, patterns of failure, and treatment outcomes. PATIENTS AND METHODS: A retrospective international study of 204 eligible patients presenting to the International Extranodal Lymphoma Study Group-affiliated institutions from 1980 to 2003. RESULTS: Median age was 64 years, with 95% of patients presenting with unilateral disease. Median overall survival (OS) was 8.0 years, and median progression-free survival 5.5 years. In multifactor analysis, favourable International Prognostic Index score, anthracycline-containing chemotherapy, and radiotherapy (RT) were significantly associated with longer OS (each P < or = 0.03). There was no benefit from mastectomy, as opposed to biopsy or lumpectomy only. At a median follow-up time of 5.5 years, 37% of patients had progressed--16% in the same or contralateral breast, 5% in the central nervous system, and 14% in other extranodal sites. CONCLUSIONS: The combination of limited surgery, anthracycline-containing chemotherapy, and involved-field RT produced the best outcome in the pre-rituximab era. A prospective trial on the basis of these results should be pursued to confirm these observations and to determine whether the impact of rituximab on the patterns of relapse and outcome parallels that of DLBCL presenting at other sites.
    Citation
    Primary diffuse large B-cell lymphoma of the breast: prognostic factors and outcomes of a study by the International Extranodal Lymphoma Study Group. 2008, 19 (2):233-41 Ann. Oncol.
    Journal
    Annals of Oncology
    URI
    http://hdl.handle.net/10541/55801
    DOI
    10.1093/annonc/mdm471
    PubMed ID
    17932394
    Type
    Article
    Language
    en
    ISSN
    1569-8041
    ae974a485f413a2113503eed53cd6c53
    10.1093/annonc/mdm471
    Scopus Count
    Collections
    All Christie Publications
    Medical Oncology

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