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dc.contributor.authorMead, Graham M
dc.contributor.authorBarrans, Sharon L
dc.contributor.authorQian, Wendi
dc.contributor.authorWalewski, Jan
dc.contributor.authorRadford, John A
dc.contributor.authorWolf, Max
dc.contributor.authorClawson, Simon
dc.contributor.authorStenning, Sally P
dc.contributor.authorYule, Claire L
dc.contributor.authorJack, Andrew S
dc.date.accessioned2009-03-16T16:37:06Z
dc.date.available2009-03-16T16:37:06Z
dc.date.issued2008-09-15
dc.identifier.citationA prospective clinicopathologic study of dose-modified CODOX-M/IVAC in patients with sporadic Burkitt lymphoma defined using cytogenetic and immunophenotypic criteria (MRC/NCRI LY10 trial). 2008, 112 (6):2248-60 Blooden
dc.identifier.issn1528-0020
dc.identifier.pmid18612102
dc.identifier.doi10.1182/blood-2008-03-145128
dc.identifier.urihttp://hdl.handle.net/10541/55797
dc.description.abstractThis prospective study aimed to develop reproducible diagnostic criteria for sporadic Burkitt lymphoma (BL), applicable to routine practice, and to evaluate the efficacy of dose-modified (dm) CODOX-M/IVAC in patients diagnosed using these criteria. The study was open to patients with an aggressive B-cell lymphoma with an MKI67 fraction approaching 100%. Immunophenotype and fluorescent in situ hybridization (FISH) were used to separate BL from other aggressive B-cell lymphomas. BL was characterized by the presence of a cMYC rearrangement as a sole cytogenetic abnormality occurring in patients with a germinal center phenotype with absence of BCL-2 expression and abnormal TP53 expression. A total of 128 patients were eligible for the study, of whom 58 were considered to have BL and 70 to have diffuse large B-cell lymphoma (DLBCL). There were 110 clinically fit patients who received dmCODOX-M (methotrexate, dose 3 g/m(2)) with or without IVAC according to risk group. The 2-year progression-free survival was 64% (95% confidence interval [CI] 51%-77%) for BL, 55% (95% CI 42%-66%) for DLBCL, 85% (95% CI 73%-97%) for low risk, and 49% (95% CI 38%-60%) for high-risk patients. The observed differences in outcome and other clinical features validate the proposed diagnostic criteria. Compared with the previous trial LY06 with full-dose methotrexate (6.7 g/m(2)), there was a reduction in toxicity with comparable outcomes. This study was registered at www.clinicaltrials.gov as NCT00040690.
dc.language.isoenen
dc.subjectBurkitt Lymphomaen
dc.subjectClinical Trialen
dc.subjectCODOX-M/IVACen
dc.subjectClinicopathologic Studyen
dc.subjectMRC/NCRI LY10 trialen
dc.subject.meshAged
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols
dc.subject.meshBurkitt Lymphoma
dc.subject.meshCyclophosphamide
dc.subject.meshCytarabine
dc.subject.meshCytogenetic Analysis
dc.subject.meshDisease-Free Survival
dc.subject.meshDoxorubicin
dc.subject.meshEtoposide
dc.subject.meshHumans
dc.subject.meshIfosfamide
dc.subject.meshImmunophenotyping
dc.subject.meshMethotrexate
dc.subject.meshMiddle Aged
dc.subject.meshTreatment Outcome
dc.subject.meshVincristine
dc.titleA prospective clinicopathologic study of dose-modified CODOX-M/IVAC in patients with sporadic Burkitt lymphoma defined using cytogenetic and immunophenotypic criteria (MRC/NCRI LY10 trial).en
dc.typeArticleen
dc.contributor.departmentSouthampton University Hospitals Trust, Southampton, United Kingdom.en
dc.identifier.journalBlooden
html.description.abstractThis prospective study aimed to develop reproducible diagnostic criteria for sporadic Burkitt lymphoma (BL), applicable to routine practice, and to evaluate the efficacy of dose-modified (dm) CODOX-M/IVAC in patients diagnosed using these criteria. The study was open to patients with an aggressive B-cell lymphoma with an MKI67 fraction approaching 100%. Immunophenotype and fluorescent in situ hybridization (FISH) were used to separate BL from other aggressive B-cell lymphomas. BL was characterized by the presence of a cMYC rearrangement as a sole cytogenetic abnormality occurring in patients with a germinal center phenotype with absence of BCL-2 expression and abnormal TP53 expression. A total of 128 patients were eligible for the study, of whom 58 were considered to have BL and 70 to have diffuse large B-cell lymphoma (DLBCL). There were 110 clinically fit patients who received dmCODOX-M (methotrexate, dose 3 g/m(2)) with or without IVAC according to risk group. The 2-year progression-free survival was 64% (95% confidence interval [CI] 51%-77%) for BL, 55% (95% CI 42%-66%) for DLBCL, 85% (95% CI 73%-97%) for low risk, and 49% (95% CI 38%-60%) for high-risk patients. The observed differences in outcome and other clinical features validate the proposed diagnostic criteria. Compared with the previous trial LY06 with full-dose methotrexate (6.7 g/m(2)), there was a reduction in toxicity with comparable outcomes. This study was registered at www.clinicaltrials.gov as NCT00040690.


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