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    A prospective observational study of chemotherapy-related nausea and vomiting in routine practice in a UK cancer centre.

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    Authors
    Molassiotis, Alexander
    Saunders, Mark P
    Valle, Juan W
    Wilson, Gregory
    Lorigan, Paul C
    Wardley, Andrew M
    Levine, Edward
    Cowan, Richard A
    Loncaster, Juliette A
    Rittenberg, C
    Affiliation
    School of Nursing, Midwifery and Social Work, University of Manchester, Coupland III, Manchester, UK. alex.molassiotis@manchester.ac.uk
    Issue Date
    2008-02
    
    Metadata
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    Abstract
    OBJECTIVE: The aim of the study was to assess levels of chemotherapy-induced nausea and vomiting (CINV) in routine practice. MATERIALS AND METHODS: The study was an observational prospective evaluation using patient self-reports. One hundred and two patients with cancer in a single cancer centre in UK receiving their first chemotherapy treatment participated in the study and were followed up over four cycles, providing a total of 272 assessments of nausea and vomiting. Data was collected with the use of the MASCC Antiemesis Tool (MAT), which is an eight-item short clinical scale assessing acute and delayed nausea and vomiting after chemotherapy. RESULTS: Results indicated that acute vomiting was experienced by 15.7% of the patients in cycle 1 and delayed vomiting by 14.7%, while acute nausea was present in 37.3% of the patients and delayed nausea in 47.1%, increasing over the subsequent cycles. Moderately emetogenic and highly emetogenic chemotherapy had the highest incidence of CINV, whereas patients receiving highly emetogenic chemotherapy showed significant levels of delayed nausea. Acute symptoms were more easily controlled than delayed symptoms. DISCUSSION: The data suggest that, while vomiting is well controlled, nausea remains a significant problem in practice, and optimal management of CINV is yet to be achieved. Understanding more clearly the biological basis of nausea will assist in managing this complex symptom more effectively in practice.
    Citation
    A prospective observational study of chemotherapy-related nausea and vomiting in routine practice in a UK cancer centre. 2008, 16 (2):201-208 Support Care Cancer
    Journal
    Supportive Care in Cancer
    URI
    http://hdl.handle.net/10541/55714
    DOI
    10.1007/s00520-007-0343-7
    PubMed ID
    17926070
    Type
    Article
    Language
    en
    ISSN
    0941-4355
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00520-007-0343-7
    Scopus Count
    Collections
    All Christie Publications
    Medical Oncology
    Clinical Oncology

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