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    Measurement of myocardial blood flow by cardiovascular magnetic resonance perfusion: comparison of distributed parameter and Fermi models with single and dual bolus.

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    Authors
    Papanastasiou, G
    Williams, M
    Kershaw, Lucy E
    Dweck, M
    Alam, S
    Mirsadraee, S
    Connell, M
    Gray, C
    MacGillivray, T
    Newby, D
    Semple, S
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    Affiliation
    Clinical Research Imaging Centre, University of Edinburgh,, Edinburgh
    Issue Date
    2015
    
    Metadata
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    Abstract
    Mathematical modeling of cardiovascular magnetic resonance perfusion data allows absolute quantification of myocardial blood flow. Saturation of left ventricle signal during standard contrast administration can compromise the input function used when applying these models. This saturation effect is evident during application of standard Fermi models in single bolus perfusion data. Dual bolus injection protocols have been suggested to eliminate saturation but are much less practical in the clinical setting. The distributed parameter model can also be used for absolute quantification but has not been applied in patients with coronary artery disease. We assessed whether distributed parameter modeling might be less dependent on arterial input function saturation than Fermi modeling in healthy volunteers. We validated the accuracy of each model in detecting reduced myocardial blood flow in stenotic vessels versus gold-standard invasive methods.
    Citation
    Measurement of myocardial blood flow by cardiovascular magnetic resonance perfusion: comparison of distributed parameter and Fermi models with single and dual bolus. 2015, 17 (1):17 J Cardiovasc Magn Reson
    Journal
    Journal of Cardiovascular Magnetic Resonance
    URI
    http://hdl.handle.net/10541/554167
    DOI
    10.1186/s12968-015-0125-1
    PubMed ID
    25885056
    Type
    Article
    Language
    en
    ISSN
    1532-429X
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12968-015-0125-1
    Scopus Count
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