Affiliation
Department of Medical Oncology, Jules Bordet Institute, Université Libre de Bruxelles, Belgium.Issue Date
2008-02
Metadata
Show full item recordAbstract
The discovery of cytotoxic agents was revolutionary for anticancer therapy in the last century, improving survival rates and the quality of life of patients with different types of tumours. However, the development of agents that combine efficacy, safety and convenience remains a great challenge, due to the narrow therapeutic index of some drugs, the fact that they may damage not only cancer cells, but also normal and healthy tissue and the occurrence of resistance, limiting anticancer efficacy. Novel cytotoxic agents have brought certain advantages over the conventional ones, such as shorter administration time, mechanisms to overcome drug resistance and lower incidence of adverse events. In this review we highlight the development of promising novel cytotoxic drugs that will hopefully offer not only gains in efficacy, but also in safety, tolerability and convenience in the treatment of patients with cancer.Citation
Novel cytotoxic drugs: old challenges, new solutions. 2008, 34 (1):81-91 Cancer Treat. Rev.Journal
Cancer Treatment ReviewsDOI
10.1016/j.ctrv.2007.08.001PubMed ID
17905518Type
ArticleLanguage
enISSN
0305-7372ae974a485f413a2113503eed53cd6c53
10.1016/j.ctrv.2007.08.001
Scopus Count
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