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    Novel cytotoxic drugs: old challenges, new solutions.

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    Authors
    Ismael, Gustavo F V
    Rosa, Daniela D
    Mano, Max S
    Awada, Ahmad
    Affiliation
    Department of Medical Oncology, Jules Bordet Institute, Université Libre de Bruxelles, Belgium.
    Issue Date
    2008-02
    
    Metadata
    Show full item record
    Abstract
    The discovery of cytotoxic agents was revolutionary for anticancer therapy in the last century, improving survival rates and the quality of life of patients with different types of tumours. However, the development of agents that combine efficacy, safety and convenience remains a great challenge, due to the narrow therapeutic index of some drugs, the fact that they may damage not only cancer cells, but also normal and healthy tissue and the occurrence of resistance, limiting anticancer efficacy. Novel cytotoxic agents have brought certain advantages over the conventional ones, such as shorter administration time, mechanisms to overcome drug resistance and lower incidence of adverse events. In this review we highlight the development of promising novel cytotoxic drugs that will hopefully offer not only gains in efficacy, but also in safety, tolerability and convenience in the treatment of patients with cancer.
    Citation
    Novel cytotoxic drugs: old challenges, new solutions. 2008, 34 (1):81-91 Cancer Treat. Rev.
    Journal
    Cancer Treatment Reviews
    URI
    http://hdl.handle.net/10541/55035
    DOI
    10.1016/j.ctrv.2007.08.001
    PubMed ID
    17905518
    Type
    Article
    Language
    en
    ISSN
    0305-7372
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ctrv.2007.08.001
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research
    Medical Oncology

    entitlement

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