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    Chronic mucocutaneous candidiasis and oesophageal cancer.

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    Authors
    Rosa, Daniela D
    Pasqualotto, Alessandro C
    Denning, David W
    Affiliation
    Paterson Institute for Cancer Research, Cancer Research UK, Manchester.
    Issue Date
    2008-02
    
    Metadata
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    Abstract
    Chronic mucocutaneous candidiasis (CMC) is often accompanied by endocrine or inflammatory disorders. The association of CMC with squamous cell carcinoma of the oral cavity or oesophagus have been described in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). We describe three cases of CMC and oesophageal cancer without the APECED syndrome. The first case refers to a 41-year-old man with Candida paronychia and oral infection and selective IgA deficiency since childhood, who later developed an oesophageal cancer. The second case is a 30-year-old man who presented CMC features at the age of 2 together with selective IgA deficiency. Later on he was diagnosed with an oesophageal squamous cell carcinoma. His mother, the third case reported, had oral thrush since childhood and at the age of 29 she presented with an oesophageal squamous cell carcinoma. The three patients reported died due to oesophageal cancer. This is the first case report describing the development of oesophageal cancer in patients with CMC without the APECED syndrome. Patients with CMC need close follow-up with good oral hygiene and aggressive treatment of oral and oesophageal candidiasis. Routine endoscopic screening for patients with CMC that develop symptoms of oesophageal candidiasis and for patients with CMC with a family history of oesophageal cancer is suggested. Avoidance of additional risk factors for oral and oesophageal cancer like cigarette smoking and excessive alcohol consumption are also warranted.
    Citation
    Chronic mucocutaneous candidiasis and oesophageal cancer. 2008, 46 (1):85-91 Med. Mycol.
    Journal
    Medical Mycology
    URI
    http://hdl.handle.net/10541/55034
    DOI
    10.1080/13693780701616023
    PubMed ID
    17852718
    Type
    Article
    Language
    en
    ISSN
    1369-3786
    ae974a485f413a2113503eed53cd6c53
    10.1080/13693780701616023
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research
    Medical Oncology

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