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    Molecular-targeted therapies: lessons from years of clinical development.

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    Authors
    Rosa, Daniela D
    Ismael, Gustavo F V
    Lago, Lissandra Dal
    Awada, Ahmad
    Affiliation
    Medical Oncology Clinic, Jules Bordet Institute, and L Universite Libre de Bruxelles (ULB), Brussels, Belgium. dornellesrosa@hotmail.com
    Issue Date
    2008-02
    
    Metadata
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    Abstract
    Over the past decade, molecular-targeted therapies have been added to cytotoxic and anti-endocrine drugs in the treatment of cancer, with the aim to target the molecular pathways that underlie the carcinogenic process and maintain the cancer phenotype. Success with some of these agents has suggested that identification and validation of the drug target is the starting point for the route of development of active, safe and effective drugs. Main molecular targets used to the development of anticancer drugs are cell surface receptors, signal transduction pathways, gene transcription targets, ubiquitin-proteasome/heat shock proteins and tumour microenvironment components (especially antiangiogenic agents). Here, we review the development of the main molecular targeted non-cytotoxic agents studied in cancer, highlighting lessons derived from the development of these novel drugs and proposing new horizons for the clinical development of molecular-targeted therapies.
    Citation
    Molecular-targeted therapies: lessons from years of clinical development. 2008, 34 (1):61-80 Cancer Treat. Rev.
    Journal
    Cancer Treatment Reviews
    URI
    http://hdl.handle.net/10541/55033
    DOI
    10.1016/j.ctrv.2007.07.019
    PubMed ID
    17826917
    Type
    Article
    Language
    en
    ISSN
    0305-7372
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ctrv.2007.07.019
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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