Molecular-targeted therapies: lessons from years of clinical development.
Affiliation
Medical Oncology Clinic, Jules Bordet Institute, and L Universite Libre de Bruxelles (ULB), Brussels, Belgium. dornellesrosa@hotmail.comIssue Date
2008-02
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Over the past decade, molecular-targeted therapies have been added to cytotoxic and anti-endocrine drugs in the treatment of cancer, with the aim to target the molecular pathways that underlie the carcinogenic process and maintain the cancer phenotype. Success with some of these agents has suggested that identification and validation of the drug target is the starting point for the route of development of active, safe and effective drugs. Main molecular targets used to the development of anticancer drugs are cell surface receptors, signal transduction pathways, gene transcription targets, ubiquitin-proteasome/heat shock proteins and tumour microenvironment components (especially antiangiogenic agents). Here, we review the development of the main molecular targeted non-cytotoxic agents studied in cancer, highlighting lessons derived from the development of these novel drugs and proposing new horizons for the clinical development of molecular-targeted therapies.Citation
Molecular-targeted therapies: lessons from years of clinical development. 2008, 34 (1):61-80 Cancer Treat. Rev.Journal
Cancer Treatment ReviewsDOI
10.1016/j.ctrv.2007.07.019PubMed ID
17826917Type
ArticleLanguage
enISSN
0305-7372ae974a485f413a2113503eed53cd6c53
10.1016/j.ctrv.2007.07.019
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