• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    A randomised comparison of daunorubicin 90mg/m2 vs 60mg/m2 in AML induction: results from the UK NCRI AML17 trial in 1206 patients.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Burnett, A
    Russell, N
    Hills, R
    Kell, J
    Cavenagh, J
    Kjeldsen, L
    McMullin, M
    Cahalin, P
    Dennis, Michael
    Friis, L
    Thomas, I
    Milligan, D
    Clark, R
    Show allShow less
    Affiliation
    Department of Haematology, Cardiff University School of Medicine, Cardiff, United Kingdom; akburnett719@gmail.comDepartment of Haematology, Nottingham University Hospital NHS Trust, Nottingham, United Kingdom;Department of Haematology, Cardiff University School of Medicine, Cardiff, United Kingdom;Department of Haematology, University Hospital of Wales, Cardiff, United Kingdom;Department of Haematology, St Bartholomew's Hospital, London, United Kingdom;Department of Haematology, Rigshospitalet, Copenhagen, Denmark;Department of Haematology, Belfast City Hospital, Belfast, United Kingdom;Blackpool Victoria Hospital, Blackpool, United Kingdom;Department of Haematology, Christie Hospital, Manchester, United Kingdom;Department of Haematology, University of Odense, Odense, Denmark;Department of Haematology, Cardiff University School of Medicine, Cardiff, United Kingdom;Department of Haematology, Heartlands Hospital, Birmingham, United Kingdom;Department of Haematology, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Issue Date
    2015-04-01
    
    Metadata
    Show full item record
    Abstract
    Modifying induction therapy in AML may improve the remission rate and reduce the risk of relapse thereby improving survival. Escalation of the daunorubicin dose to 90mg/m(2) has shown benefit for some patient subgroups when compared with a dose of 45mg/m(2) and has been recommended as a standard of care. However 60mg/m(2) is widely used and has never been directly compared to 90mg/m(2). As part of the UK NCRI AML17 trial 1206 adults with untreated AML or high risk MDS, mostly under 60 years of age, were randomised to a first induction course of chemotherapy which delivered either 90mg/m(2) or 60mg/m(2) on days 1,3 and 5 combined with cytosine arabinoside. All patients then received a second course which included daunorubicin 50mg/m(2) on days 1,3 and 5. There was no overall difference in complete remission rate (CR) (73% vs 75%, OR1.07 (0.83-1.39), p=0.6) or in any recognised subgroup. The 60 day mortality was increased in the 90mg/m2 arm (10% vs 5% (HR 1.98(1.30-3.02) p=0.001)), which resulted in no difference in overall 2 year survival (59% vs 60%, HR 1.16(0.95-1.43), p=0.15). In exploratory subgroup analysis there was no subgroup which showed significant benefit, although there was a significant interaction by FLT3 ITD mutation. The trial is registered to www.isrctn.com as ISRCTN55675535.
    Citation
    A randomised comparison of daunorubicin 90mg/m2 vs 60mg/m2 in AML induction: results from the UK NCRI AML17 trial in 1206 patients. 2015: Blood
    Journal
    Blood
    URI
    http://hdl.handle.net/10541/550240
    DOI
    10.1182/blood-2015-01-623447
    PubMed ID
    25833957
    Type
    Article
    Language
    en
    ISSN
    1528-0020
    ae974a485f413a2113503eed53cd6c53
    10.1182/blood-2015-01-623447
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Measurable Residual Disease at Induction Redefines Partial Response in Acute Myeloid Leukemia and Stratifies Outcomes in Patients at Standard Risk Without NPM1 Mutations.
    • Authors: Freeman SD, Hills RK, Virgo P, Khan N, Couzens S, Dillon R, Gilkes A, Upton L, Nielsen OJ, Cavenagh JD, Jones G, Khwaja A, Cahalin P, Thomas I, Grimwade D, Burnett AK, Russell NH
    • Issue date: 2018 May 20
    • Bortezomib added to daunorubicin and cytarabine during induction therapy and to intermediate-dose cytarabine for consolidation in patients with previously untreated acute myeloid leukemia age 60 to 75 years: CALGB (Alliance) study 10502.
    • Authors: Attar EC, Johnson JL, Amrein PC, Lozanski G, Wadleigh M, DeAngelo DJ, Kolitz JE, Powell BL, Voorhees P, Wang ES, Blum W, Stone RM, Marcucci G, Bloomfield CD, Moser B, Larson RA
    • Issue date: 2013 Mar 1
    • Daunorubicin 90 mg/m(2) in Acute Myeloid Leukemia Induction: Increased Toxicity in Young Patients.
    • Authors: Portugal R, Lyrio R, Loureiro M, Urago K, Bard J, Borchardt A, Garnica M, Nucci M
    • Issue date: 2017 Aug
    • Phase 2 trial of CPX-351, a fixed 5:1 molar ratio of cytarabine/daunorubicin, vs cytarabine/daunorubicin in older adults with untreated AML.
    • Authors: Lancet JE, Cortes JE, Hogge DE, Tallman MS, Kovacsovics TJ, Damon LE, Komrokji R, Solomon SR, Kolitz JE, Cooper M, Yeager AM, Louie AC, Feldman EJ
    • Issue date: 2014 May 22
    • Anthracycline dose intensification in acute myeloid leukemia.
    • Authors: Fernandez HF, Sun Z, Yao X, Litzow MR, Luger SM, Paietta EM, Racevskis J, Dewald GW, Ketterling RP, Bennett JM, Rowe JM, Lazarus HM, Tallman MS
    • Issue date: 2009 Sep 24
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.