Allogeneic transplant following brentuximab vedotin in patients with relapsed or refractory Hodgkin lymphoma and systemic anaplastic large cell lymphoma.
Authors
Illidge, Timothy MBouabdallah, R
Chen, R
Gopal, A
Moskowitz, C
Ramchandren, R
Shustov, A
Tilly, H
Trippett, T
Gibb, Adam
Grove, L
Advani, R
Affiliation
Institute of Cancer Sciences, Manchester University , Manchester , UKIssue Date
2015-03
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Show full item recordAbstract
Brentuximab vedotin is an antibody drug conjugate that induces durable objective responses in patients with relapsed or refractory Hodgkin lymphoma and systemic anaplastic large cell lymphoma. Fifteen of 160 patients who participated in two pivotal phase 2 studies received a consolidative allogeneic stem cell transplant (allo-SCT) following brentuximab vedotin treatment. This case series describes their experience. The studies were approved by Institutional Review Boards prior to patient enrollment. Patients received 1.8 mg/kg brentuximab vedotin every 3 weeks for up to 16 cycles. The estimated 2-year progression-free survival (PFS) rate was 66%, and the median PFS has not yet been reached. Eleven of the 15 patients were alive and the estimated 2-year survival rate was 80%. The safety of brentuximab vedotin treatment in this series was consistent with the known safety profile in this setting. Brentuximab vedotin is a compelling option for reducing tumor burden to facilitate a consolidative allo-SCT.Citation
Allogeneic transplant following brentuximab vedotin in patients with relapsed or refractory Hodgkin lymphoma and systemic anaplastic large cell lymphoma. 2015, 56 (3):703-10 Leuk LymphomaJournal
Leukemia & LymphomaDOI
10.3109/10428194.2014.930852PubMed ID
24913507Type
ArticleLanguage
enISSN
1029-2403ae974a485f413a2113503eed53cd6c53
10.3109/10428194.2014.930852
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